Technology Process of 5-bromo-4-chloroisobenzofuran-1(3H)-one
There total 4 articles about 5-bromo-4-chloroisobenzofuran-1(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3-bromo-2-chloro-phenyl)methanol;
With
trifluoroacetic acid; thallium(III) trifluoroacetate;
at 20 ℃;
for 16h;
carbon monoxide;
With
magnesium oxide; lithium chloride; palladium dichloride;
In
ethanol;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: zinc; ammonium formate; acetic acid / methanol; tetrahydrofuran / 18 h / 20 °C
2.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C
2.2: 0 - 60 °C
3.1: lithium triethylborohydride / tetrahydrofuran / 16 h / 0 °C
4.1: trifluoroacetic acid; thallium(III) trifluoroacetate / 16 h / 20 °C
4.2: 20 °C
With
hydrogen bromide; ammonium formate; lithium triethylborohydride; acetic acid; trifluoroacetic acid; zinc; sodium nitrite; thallium(III) trifluoroacetate;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C
1.2: 0 - 60 °C
2.1: lithium triethylborohydride / tetrahydrofuran / 16 h / 0 °C
3.1: trifluoroacetic acid; thallium(III) trifluoroacetate / 16 h / 20 °C
3.2: 20 °C
With
hydrogen bromide; lithium triethylborohydride; trifluoroacetic acid; sodium nitrite; thallium(III) trifluoroacetate;
In
tetrahydrofuran; water;
