Boc-His(1-Boc)-Osu

Base Information

• Chemical Name: Boc-His(1-Boc)-Osu
• CAS No.: 25616-02-8
• Molecular Formula: C20H28N4O8
• Molecular Weight: 452.461
• DSSTox Substance ID: DTXSID60566637
• Wikidata: Q82452339
• Mol file: 25616-02-8.mol

Synonyms:Boc-His(1-Boc)-Osu;25616-02-8;tert-butyl 4-[(2S)-3-(2,5-dioxopyrrolidin-1-yl)oxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxopropyl]imidazole-1-carboxylate;Boc-his(tau-boc)-osu;Boc-L-His(Boc)-OSu;Boc-His(-Boc)-OSu;SCHEMBL3745036;DTXSID60566637;Nalpha,Nim-Bis-Boc-L-histidine N-hydroxysuccinimide ester;MFCD00236852;AKOS015999066;FD21733;AS-49188;CS-0362661;J-016068;N alpha ,Nim-Bis-Boc-L-histidine N-hydroxysuccinimide ester;2,5-Dioxopyrrolidin-1-yl N,1-bis(tert-butoxycarbonyl)-L-histidinate;Tert-butyl (S)-4-(2-((tert-butoxycarbonyl)amino)-3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropyl)-1H-imidazole-1-carboxylate

Chemical Property of Boc-His(1-Boc)-Osu

Chemical Property:

• PSA: 146.13000
• LogP: 2.03810
• Storage Temp.: Store at 0°C
• Solubility.: DMSO (Slightly), Ethyl Acetate (Slightly)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 10
• Exact Mass: 452.19071386
• Heavy Atom Count: 32
• Complexity: 755

Purity/Quality:

97% ^*data from raw suppliers

Boc-his(1-boc)-osu ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CC1=CN(C=N1)C(=O)OC(C)(C)C)C(=O)ON2C(=O)CCC2=O
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CC1=CN(C=N1)C(=O)OC(C)(C)C)C(=O)ON2C(=O)CCC2=O

Technology Process of Boc-His(1-Boc)-Osu

There total 3 articles about Boc-His(1-Boc)-Osu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine (20866-46-0) → Nα, Nim-di-Boc-L-histidine N-hydroxysuccinimide ester (25616-02-8)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1039/a706711i

Reference yield:

→ N-(1,Nα-bis-tert-butoxycarbonyl-histidyloxy)-succinimide (25616-02-8)

Guidance literature:

N^α,N^im-Di-Boc-histidin;

DOI:10.1007/BF00563997

Reference yield:

→ Nα, Nim-di-Boc-L-histidine N-hydroxysuccinimide ester (25616-02-8)

Guidance literature:

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine

Downstream raw materials:

[(S)-1-((1S,2S,4S)-4-Butylcarbamoyl-1-cyclohexylmethyl-2-hydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester

(2S,3S,5S)-N-<1-cyclohexyl-3-hydroxyl-6-methyl-5-<<<2-(4-morpholinyl)ethoxy>carbonyl>amino>heptan-2-yl>(tert-butyloxycarbonyl)L-histidinamide