1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
CAS No.:301326-22-7
Molecular Formula:C19H19N5O
Molecular Weight:333.38706
Hs Code.:
European Community (EC) Number:683-682-8
UNII:HYE7315Z4C
DSSTox Substance ID:DTXSID5058698,DTXSID001045956
Nikkaji Number:J3.005.551I
Wikidata:Q27216129,Q27280162
ChEMBL ID:CHEMBL1743245
Mol file:301326-22-7.mol

Synonyms:1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide;CH 223191;1-Methyl-N-[2-methyl-4-[(2-methylphenyl)azo]phenyl]-1H-pyrazole-5-carboxamide;AhR Antagonist;2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide;2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide;(E)-1-methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide

Suppliers and Price of 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CH 223191
10mg
$ 423.00

Usbiological
CH 223191
10mg
$ 356.00

TRC
CH223191
5mg
$ 65.00

Tocris
CH223191 ≥98%(HPLC)
50
$ 732.00

Tocris
CH223191 ≥98%(HPLC)
10
$ 174.00

Sigma-Aldrich
AhR Antagonist
10mg
$ 161.87

Sigma-Aldrich
CH-223191
5mg
$ 98.60

Sigma-Aldrich
CH-223191
25mg
$ 398.00

DC Chemicals
CH-223191 >98%
1 g
$ 1600.00

DC Chemicals
CH-223191 >98%
100 mg
$ 448.00

Total 27 raw suppliers

Chemical Property of 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Chemical Property:

Boiling Point:469.4±45.0 °C(Predicted)
PKA:12.98±0.70(Predicted)
PSA：75.13000
Density:1.20±0.1 g/cm3(Predicted)
LogP:5.08860
Storage Temp.:Store at +4°C
Solubility.:DMSO: ≥20mg/mL
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:333.15896025
Heavy Atom Count:25
Complexity:482

Purity/Quality:

99%, ^*data from raw suppliers

CH 223191 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22
Safety Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C
Description CH-221391 (CAS 301326-22-7) is an arylhydrocarbon (AhR) receptor antagonist, IC50=30 nM.1 Blocks endogenous AhR agonist-induced differentiation of Th17 cells.2?? Promotes expansion of human hematopoietic stem cells.3 Mitigates cytokine-mediated inflammatory signaling in human fibroblast-like synoviocytes.4 An important tool for probing the involvement of AhR in the toxicity of various environmental toxins such as TCDD and other dioxins.5
Uses CH-223191 has been used as aryl hydrocarbon receptor (AHR) antagonist in HepaRG cells, TH17-IL-10+ cells and organoids.

Technology Process of 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

There total 1 articles about 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 16034-46-1
1-methyl-1H-pyrazole-5-carboxylic acid

: 97-56-3
o-aminoazotoluene

: 301326-22-7
(E)-1-methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,2-dichloro-ethane; at 120 ℃; for 0.366667h; Microwave irradiation;
DOI:10.1124/mol.114.093369