Technology Process of tert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate
There total 7 articles about tert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
mono-tert-butyl malonate;
With
triethylamine; magnesium chloride;
In
tetrahydrofuran;
at 10 - 30 ℃;
for 2h;
Inert atmosphere;
2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 10 - 65 ℃;
for 7h;
Inert atmosphere;
- Guidance literature:
-
With
sodium methylate;
In
methanol;
at 50 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / -10 °C
2.1: zinc dibromide / 95 °C
3.1: sodium hydroxide; water / methanol / Reflux
4.1: N-iodo-succinimide; methanesulfonic acid / acetonitrile / 15 - 25 °C
5.1: magnesium chloride; triethylamine / tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere
5.2: 7 h / 10 - 65 °C / Inert atmosphere
With
aluminum (III) chloride; N-iodo-succinimide; methanesulfonic acid; water; triethylamine; sodium hydroxide; magnesium chloride; zinc dibromide;
In
tetrahydrofuran; methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; acetonitrile;
