1256584-73-2

Basic information

• Product Name: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
• Synonyms: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid;2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid-7;4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid;4-Ethyl-3-iodo-alpha,alpha-dimethylbenzeneacetic acid;2-(3-Iodo-4-ethylphenyl)-2-methylpropionic acid
• CAS NO: 1256584-73-2
• Molecular Formula: C12H15IO2
• Molecular Weight: 318.15077
• Mol File: 1256584-73-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 369.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.547±0.06 g/cm3(Predicted)
• PKA: 4.32±0.11(Predicted)
• CAS DataBase Reference: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid(1256584-73-2)
• EPA Substance Registry System: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid(1256584-73-2)

Safety Data

• Hazardous Substances Data: 1256584-73-2(Hazardous Substances Data)

Usage

Uses

2-?(4-?Ethyl-?3-?iodophenyl)?-?2-?methylpropanoic Acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Upstream product

• 826-55-1 2-methyl-2-phenylpropionic acid 
• 937-30-4 4-ethylacetophenone 
• 857768-18-4 2-(4-acetyl-phenyl)-2-methyl-propionic acid 
• 57625-74-8 methyl 2-methyl-2-phenylpropionate 
• 14387-10-1 (4-ethyl-phenyl)-acetic acid 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 698394-59-1 methyl 2-(4-ethylphenyl)-2-methyl-propanoate 
• 698394-60-4 2-bromo-1-(4-ethylphenyl)-2-methyl-propan-1-one 
• 100-41-4 ethylbenzene 
• 1247119-83-0 2-(4-ethylphenyl)-2-methyl-propanoic acid 
• 85010-92-0 2-(4-ethylphenyl)-2-methyl-1-propanol 
• 91561-14-7 1-chloro-2-(4-ethylphenyl)-2-methylpropane 

Downstream Products

• 1256580-46-7 C⁽²⁴⁸⁾H₅₄₀₂ 

Relevant articles and documents

Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK)

A series of novel anaplastic lymphoma kinase (ALK) degraders were designed and synthesized based on proteolysis-targeting chimera (PROTAC) technology by linking two alectinib analogs (36 and 37) with pomalidomide through linkers of different lengths and types. The most promising degrader 17 possessed a high ALK-binding affinity and potent antiproliferative activity in the ALK-dependent cell lines and did not exhibit obvious cytotoxicity in ALK fusion-negative cells. More importantly, the efficacy of compound 17 in a Karpas 299 xenograft mouse model was further evaluated based on its ALK-sustained degradation ability in vivo. The reduction in tumor weight in the compound 17-treated group (10 mg/kg/day, I.V.) reached 75.82%, while alectinib reduced tumor weight by 63.82% at a dose of 20 mg/kg/day (P.O.). Taken together, our findings suggest that alectinib-based PROTACs associated with the degradation of ALK may have promising beneficial effects for treating ALK-driven malignancies.

Preparation method and intermediate of halogenated aromatic hydrocarbon compound

The invention discloses a preparation method and an intermediate of a halogenated aromatic hydrocarbon compound, wherein the preparation method has the advantages of simple and accessible raw materials, low reagent price, high yield and simple operation,

Method for synthesizing alecensa hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid

The invention discloses a method for synthesizing an alecensa hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid. The method is characterized by comprising steps of carrying out Friedel-Crafts reaction on ethylbenzene and 3-halogen-2-methyl-1-propylene to obtain 1-halogn-2-(4-ethyl phenyl)-2-methylpropane; carrying out reaction on the 1-halogn-2-(4-ethyl phenyl)-2-methylpropane and magnesium to obtain 2-(4-ethyl phenyl)-2-methyl propyl magnesium halide; carrying out reaction on the 2-(4-ethyl phenyl)-2-methyl propyl magnesium halide and oxygen to obtain 2-(4-ethyl phenyl)-2-methyl-1-propyl alcohol; oxidizing the 2-(4-ethyl phenyl)-2-methyl-1-propyl alcohol, sodium hypochlorite and sodium chlorite by the aid of 2,2,6,6-tetramethyl piperidine oxide to obtain 2-(4-ethyl phenyl)-2-methylpropanoic acid; carrying out reaction on the 2-(4-ethyl phenyl)-2-methylpropanoic acid and iodine in the presence of oxidizing agents under acidic conditions to obtain the alecensa hydrochloride intermediate. 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid. The 2,2,6,6-tetramethyl piperidine oxide is used as a catalyst. The method has the advantages that the method is easy and convenient to operate, high in yield, low in cost and little in pollution, raw materials for the alecensa hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid are inexpensive and are easily available, and industrial production can be facilitated.