4-Chloro-6-methoxy-2-methylquinazoline

Base Information

• Chemical Name: 4-Chloro-6-methoxy-2-methylquinazoline
• CAS No.: 60395-90-6
• Molecular Formula: C10H9ClN2O
• Molecular Weight: 208.647
• European Community (EC) Number: 861-191-1
• DSSTox Substance ID: DTXSID501282397
• Mol file: 60395-90-6.mol

Synonyms:4-chloro-6-methoxy-2-methylquinazoline;60395-90-6;4-chloro-6-methoxy-2-methyl-quinazoline;SCHEMBL1257525;YOQQPWWCYHJCGV-UHFFFAOYSA-N;DTXSID501282397;AMY27448;MFCD12024901;AKOS022178430;2-methyl-4-chloro-6-methoxyquinazoline;AS-63573;CS-0152821;EN300-114654;Z1269116899

Chemical Property of 4-Chloro-6-methoxy-2-methylquinazoline

Chemical Property:

• PSA: 35.01000
• LogP: 2.60020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 208.0403406
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

97% ^*data from raw suppliers

4-chloro-6-methoxy-2-methylquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(C=C(C=C2)OC)C(=N1)Cl

Technology Process of 4-Chloro-6-methoxy-2-methylquinazoline

There total 3 articles about 4-Chloro-6-methoxy-2-methylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

6-methoxy-2-methylquinazolin-4-ol (51413-71-9) → 4-chloro-6-methoxy-2-methylquinazoline (60395-90-6)

Guidance literature:

With trichlorophosphate; for 60h; Reflux;

DOI:10.1016/j.ejmech.2016.10.014

Reference yield:

2-Amino-5-methoxybenzoic acid (6705-03-9) → 4-chloro-6-methoxy-2-methylquinazoline (60395-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 h / 165 °C / Microwave irradiation

2: trichlorophosphate / 60 h / Reflux

With trichlorophosphate;

DOI:10.1016/j.ejmech.2016.10.014

Reference yield:

→ 4-chloro-6-methoxy-2-methylquinazoline (60395-90-6)

Guidance literature:

2-Methyl-6-methoxy-4-chinazolon, POCl3, Dimethylanilin;

DOI:10.1007/BF00757841

upstream raw materials:

2-Amino-5-methoxybenzoic acid

6-methoxy-2-methylquinazolin-4-ol

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