6-METHOXY-2-METHYLQUINAZOLIN-4-OL

Base Information

• Chemical Name: 6-METHOXY-2-METHYLQUINAZOLIN-4-OL
• CAS No.: 51413-71-9
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.202
• Hs Code.: 2933990090
• Mol file: 51413-71-9.mol

Synonyms:6-methoxy-2-methylquinazolin-4-ol;6-Methoxy-2-methyl-3H-quinazolin-4-one;

Chemical Property of 6-METHOXY-2-METHYLQUINAZOLIN-4-OL

Chemical Property:

• PSA: 55.24000
• LogP: 1.65240

Purity/Quality:

98%min ^*data from raw suppliers

6-methoxy-2-methylquinazolin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHOXY-2-METHYLQUINAZOLIN-4-OL

There total 10 articles about 6-METHOXY-2-METHYLQUINAZOLIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl acetoacetate (141-97-9) + 2-amino-5-methoxybenzamide (1882-71-9) → 6-methoxy-2-methylquinazolin-4(3H)-one (51413-71-9)

Guidance literature:

With ethanolamine-phosphoric acid functionalized polyacrylonitrile fibers (PAN_EAPF); In water; at 100 ℃; for 15h; Green chemistry;

DOI:10.1039/c7gc02935g

Reference yield: 98.0%

acetamidine hydrochloride (124-42-5) + 2-bromo-5-methoxy-benzoic acid (22921-68-2) → 6-methoxy-2-methylquinazolin-4(3H)-one (51413-71-9)

Guidance literature:

With C₂₆H₂₄Cu₂N₈⁽²⁺⁾*2F₆P^(1-); caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1002/aoc.3177

Reference yield: 94.0%

2-amino-5-methoxybenzamide (1882-71-9) + acetylacetone (123-54-6,81235-32-7) → 6-methoxy-2-methylquinazolin-4(3H)-one (51413-71-9)

Guidance literature:

With ytterbium(III) triflate; In 1,3,5-trimethyl-benzene; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.3987/COM-15-S(T)59

upstream raw materials:

4-methoxyacetanilide

urethane

acetamidine hydrochloride

2-bromo-5-methoxy-benzoic acid

Downstream raw materials:

4-chloro-6-methoxy-2-methylquinazoline

Refernces

• 1、 -. "NOVEL BENZYLAMINO SUBSTITUTED QUINAZOLINES AND DERIVATIVES AS SOS1 INHIBITORS". Page/Page column 89-90. . Retrieved 2018/07/29.
• 2、 Xu, Gang,Wang, Lu,Li, Mengmeng,Tao, Minli,Zhang, Wenqin. "Phosphorous acid functionalized polyacrylonitrile fibers with a polarity tunable surface micro-environment for one-pot C-C and C-N bond formation reactions". supporting information. p. 5818 - 5830. Retrieved 2017/12/26.