Technology Process of Methyl 3-aMino-6-chloro-2-Methylisonicotinate
There total 6 articles about Methyl 3-aMino-6-chloro-2-Methylisonicotinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
for 7h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tert-butyl alcohol / 12 h / 50 °C
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / -78 - -10 °C
2.2: 0.5 h
2.3: pH ~ 3
3.1: potassium hydroxide; water / 5 h / 90 °C
3.2: 20 °C
4.1: methanol; diethyl ether; toluene / 2 h / 20 °C
5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 27 h / 20 - 80 °C
6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 7 h / Heating / reflux
With
potassium hydroxide; N-Bromosuccinimide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; water; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / N,N-dimethyl-formamide / 27 h / 20 - 80 °C
2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 7 h / Heating / reflux
With
N-Bromosuccinimide; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water; N,N-dimethyl-formamide;