Technology Process of Methyl 3-aMino-6-chloro-2-Methylisonicotinate
There total 6 articles about Methyl 3-aMino-6-chloro-2-Methylisonicotinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
for 7h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tert-butyl alcohol / 12 h / 50 °C
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / -78 - -10 °C
2.2: 0.5 h
2.3: pH ~ 3
3.1: potassium hydroxide; water / 5 h / 90 °C
3.2: 20 °C
4.1: methanol; diethyl ether; toluene / 2 h / 20 °C
5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 27 h / 20 - 80 °C
6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 7 h / Heating / reflux
With
potassium hydroxide; N-Bromosuccinimide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; water; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / N,N-dimethyl-formamide / 27 h / 20 - 80 °C
2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 7 h / Heating / reflux
With
N-Bromosuccinimide; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water; N,N-dimethyl-formamide;
