2-(2-Methylphenyl)-1,3-thiazole-4-carboxylic acid

Base Information

Chemical Name:2-(2-Methylphenyl)-1,3-thiazole-4-carboxylic acid
CAS No.:115311-25-6
Molecular Formula:C₁₁H₉NO₂S
Molecular Weight:219.264
Hs Code.:
European Community (EC) Number:849-933-2
Mol file:115311-25-6.mol

Synonyms:115311-25-6;2-(2-methylphenyl)-1,3-thiazole-4-carboxylic acid;2-(o-Tolyl)thiazole-4-carboxylic acid;SCHEMBL3536997;XXUMWTWIZGPWAY-UHFFFAOYSA-N;2-o-tolyl-thiazole-4-carboxylic acid;2-(o-Tolyl)thiazole-4-carboxylicacid;AKOS009311522;BS-30147;EN300-66772;Z381355514

Suppliers and Price of 2-(2-Methylphenyl)-1,3-thiazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 2-(2-Methylphenyl)-1,3-thiazole-4-carboxylic acid

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:219.03539970
Heavy Atom Count:15
Complexity:247

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=CC=C1C2=NC(=CS2)C(=O)O

Technology Process of 2-(2-Methylphenyl)-1,3-thiazole-4-carboxylic acid

There total 2 articles about 2-(2-Methylphenyl)-1,3-thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 885278-51-3
2-o-tolylthiazole-4-carboxylic acid ethyl ester

: 115311-25-6
2-o-tolylthiazole-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

: 16419-60-6
2-Methylphenylboronic acid

: 115311-25-6
2-o-tolylthiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; toluene / 90 °C / Inert atmosphere

2: sodium hydroxide / water; methanol; tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: (3S)-1-pyrrolo[1,2-a]pyrazin-1-ylpyrrolidin-3-amine dihydrochloride

: 115311-25-6
2-o-tolylthiazole-4-carboxylic acid

: 1613022-24-4
2-o-tolylthiazole-4-carboxylic acid (1-pyrrolo[1,2-a]pyrazin-1-yl-pyrrolidin-3-yl)-amide

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; for 0.5h;