5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-PyriMidineacetic Acid

Base Information

• Chemical Name: 5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-PyriMidineacetic Acid
• CAS No.: 56059-30-4
• Molecular Formula: C6H5FN2O4
• Molecular Weight: 188.115
• Hs Code.: 2933599090
• Mol file: 56059-30-4.mol

Synonyms:5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-PyriMidineacetic Acid;5-Fluorouracil-1-yl acetic acid;2-(5-Fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid

Chemical Property of 5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-PyriMidineacetic Acid

Chemical Property:

• Melting Point: 253-256 °C
• PKA: 3.81±0.10(Predicted)
• PSA: 92.16000
• Density: 1.69±0.1 g/cm3(Predicted)
• LogP: -1.23970
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-3,4-dihydro-2,4-dioxo-1(2h)-pyrimidineaceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-PyriMidineacetic Acid

There total 10 articles about 5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-PyriMidineacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.46%

5-fluorouracil (51-21-8) + bromoacetic acid (79-08-3) → 5-fluorouracil-1-acetic acid (56059-30-4)

Guidance literature:

With sodium hydroxide; In water; at 40 ℃; for 14h;

Reference yield: 89.0%

ethyl ω-N1-[5-fluoro-2,4(1H,3H)pyrimidinedione] acetate (56059-27-9) → 5-fluorouracil-1-acetic acid (56059-30-4)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 18h;

Reference yield: 85.1%

5-fluorouracil (51-21-8) + chloroacetic acid (79-11-8) → 5-fluorouracil-1-acetic acid (56059-30-4)

Guidance literature:

With potassium hydroxide; In water; at 100 ℃; for 2h; pH=10;

DOI:10.1039/c1cc13821a

upstream raw materials:

5-fluorouracil

sodium monochloroacetic acid

ethyl ω-N₁-[5-fluoro-2,4(1H,3H)pyrimidinedione] acetate

chloroacetic acid

Downstream raw materials:

(S)-methyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)-2-phenylacetate

(S)-methyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)-3-(4-hydroxyphenyl)propanoate

(R)-ethyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)-3-(4-hydroxyphenyl)propanoate

5,7-dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate