4-BroMo-2-Methoxy-3,5-diMethylpyridine

Base Information

• Chemical Name: 4-BroMo-2-Methoxy-3,5-diMethylpyridine
• CAS No.: 1380389-33-2
• Molecular Formula: C8H10BrNO
• Molecular Weight: 216.0751
• Hs Code.: 2933399090
• Mol file: 1380389-33-2.mol

Synonyms:4-BroMo-2-Methoxy-3,5-diMethylpyridine

Chemical Property of 4-BroMo-2-Methoxy-3,5-diMethylpyridine

Chemical Property:

• Boiling Point: 247.0±35.0 °C(Predicted)
• PKA: 4.23±0.10(Predicted)
• PSA: 22.12000
• Density: 1.390±0.06 g/cm3(Predicted)
• LogP: 2.46950
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-bromo-2-methoxy-3,5-dimethylpyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-2-Methoxy-3,5-diMethylpyridine

There total 6 articles about 4-BroMo-2-Methoxy-3,5-diMethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-bromo-3,5-dimethyl-pyridin-2-ol (1380389-34-3) + methyl iodide (74-88-4) → 4-bromo-2-methoxy-3,5-dimethylpyridine (1380389-33-2)

Guidance literature:

With silver carbonate; In chloroform; at 20 ℃; Reflux;

Reference yield: 66.61%

2-methoxy-3,5-dimethylpyridine-4-amine (1429510-61-1) → 4-bromo-2-methoxy-3,5-dimethylpyridine (1380389-33-2)

Guidance literature:

With tert.-butylnitrite; copper(I) bromide; In acetonitrile; at 70 ℃; for 1h;

Reference yield:

4-bromo-3,5-dimethyl-pyridine 1-oxide (70564-92-0) → 4-bromo-2-methoxy-3,5-dimethylpyridine (1380389-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 2.5 h / 20 °C

2: silver carbonate / chloroform / 20 °C / Reflux

With triethylamine; silver carbonate; trifluoroacetic anhydride; In tetrahydrofuran; chloroform;

upstream raw materials:

4-bromo-3,5-dimethyl-pyridin-2-ol

methyl iodide

4-bromo-3,5-dimethyl-pyridine 1-oxide

3,5-Dimethylpyridine N-oxide

Refernces

• 1、 -. "SALT OF PYRAZOLOQUINOLINE DERIVATIVE, AND CRYSTAL THEREOF". . . Retrieved 2016/05/02.
• 2、 -. "INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS". Page/Page column 97-98. . Retrieved 2012/06/16.