2-(4-BROMO-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 2-(4-BROMO-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 943750-38-7
• Molecular Formula: C15H20BrNO2
• Molecular Weight: 326.233
• Hs Code.: 2933990090
• Mol file: 943750-38-7.mol

Synonyms:2-(4-BROMO-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 2-(4-bromophenyl)-pyrrolidine-1-carboxylate

Chemical Property of 2-(4-BROMO-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 382.9±42.0 °C(Predicted)
• PKA: -2.25±0.40(Predicted)
• PSA: 29.54000
• Density: 1.319±0.06 g/cm3(Predicted)
• LogP: 4.45900
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 2-(4-bromophenyl)-pyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-BROMO-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 8 articles about 2-(4-BROMO-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-(4-azidobutyl)-4-bromobenzene → 2-(4-bromo-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (943750-38-7,328546-99-2)

Guidance literature:

With iron(II)-tetra-tert-butylphthalocyaninato complex with an axial pyridine ligand; In toluene; at 130 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1039/d1cc04573c

Reference yield: 92.0%

2-(4-bromo-phenyl)-pyrrolidine (383127-22-8) + di-tert-butyl dicarbonate (24424-99-5) → 2-(4-bromo-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (943750-38-7,328546-99-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

4-(p-bromophenyl)-butan-1-ol (75906-36-4) → 2-(4-bromo-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (943750-38-7,328546-99-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; dmap / dichloromethane / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 80 °C

3: iron(II)-tetra-tert-butylphthalocyaninato complex with an axial pyridine ligand / toluene / 130 °C / Schlenk technique; Inert atmosphere

With dmap; sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1039/d1cc04573c

upstream raw materials:

2-(4-bromo-phenyl)-pyrrolidine

di-tert-butyl dicarbonate

5-(4-bromophenyl)-3,4-dihydro-2H-pyrrole

4-methoxycarbonylphenyl bromide

Downstream raw materials:

tert-butyl 2-(4'-((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-hydroxypropyl)-[1,1'-biphenyl]-4-yl)pyrrolidine-1-carboxylate

tert-butyl 2-[4-(6-chloro-3-formyl-1H-indol-5-yl)phenyl]pyrrolidine-1-carboxylate

2-(4-bromophenyl)pyrrolidine hydrogen chloride

2-(4-bromophenyl)-1-(methylsulfonyl)pyrrolidine

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