383127-22-8

Basic information

• Product Name: 2-(4-BROMO-PHENYL)-PYRROLIDINE
• Synonyms: AKOS BB-8866;2-(4-BROMO-PHENYL)-PYRROLIDINE;Pyrrolidine, 2-(4-bromophenyl)-;1-Bromo-4-(pyrrolidin-2-yl)benzene;2-(4-BROMOPHENYL)PYRROLIDINE HYDROCHLORIDE;MFCD11506298
• CAS NO: 383127-22-8
• Molecular Formula: C₁₀H₁₂BrN
• Molecular Weight: 226.11
• Product Categories: bromophenyl，pyrrolidine
• Mol File: 383127-22-8.mol

Chemical Properties

• Boiling Point: 287.2 °C at 760 mmHg
• Flash Point: 127.5 °C
• Appearance: /
• Density: 1.369 g/cm³
• Vapor Pressure: 0.00252mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-(4-BROMO-PHENYL)-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMO-PHENYL)-PYRROLIDINE(383127-22-8)
• EPA Substance Registry System: 2-(4-BROMO-PHENYL)-PYRROLIDINE(383127-22-8)

Safety Data

• Hazardous Substances Data: 383127-22-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(4-BROMO-PHENYL)-PYRROLIDINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 2-(4-BROMO-PHENYL)-PYRROLIDINE is utilized as a component in research aimed at discovering and optimizing the properties of novel drug candidates. Its unique structure allows for exploration of its interactions with biological targets, potentially leading to advancements in drug design.
Used in Organic Compounds Synthesis:
2-(4-BROMO-PHENYL)-PYRROLIDINE is also used as an intermediate in the synthesis of a range of organic compounds, where its 4-bromo-phenyl group can be further modified or serve as a functional group for additional chemical reactions, expanding the scope of organic chemistry.
It is crucial to handle 2-(4-BROMO-PHENYL)-PYRROLIDINE with caution due to its potential hazardous properties. Only trained professionals should work with 2-(4-BROMO-PHENYL)-PYRROLIDINE in a controlled laboratory environment to ensure safety and proper use.

InChI:InChI=1/C10H12BrN/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h3-6,10,12H,1-2,7H2

Upstream product

• 22217-79-4 5-(4-bromophenyl)-3,4-dihydro-2H-pyrrole 
• 84702-76-1 4-azido-4'-bromobutylphenone 
• 4559-96-0 1-(4-bromophenyl)-4-chlorobutan-1-one 
• 1207455-72-8 tert-butyl (4-(4-bromophenyl)-4-oxobutyl)carbamate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 106-37-6 1.4-dibromobenzene 
• 123-75-1 pyrrolidine 
• 22480-64-4 4-bromophenyllithium 

Downstream Products

• 1109230-99-0 2-(4-bromophenyl)-1-methylpyrrolidine 

Relevant articles and documents

INDOLO HEPTAMYL OXIME ANALOGUE AS PARP INHIBITOR

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Direct α-C-H bond functionalization of unprotected cyclic amines

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DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

THIAZOLYL-DIHYDRO-INDAZOLES

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(Chemical Equation Presented) A series of meta- and para-substituted 2-arylpyrrolidines were synthesized and examined for their ability to catalyze an aqueous aldol reaction under buffered conditions. Kinetic analysis of arylpyrrolidine-catalyzed reactions displayed a linear Hammett correlation with ρ = 1.14 (R2 = 0.996), indicating that the reaction is accelerated by electron-withdrawing aryl rings. These results show promise for the development of a synthetically viable aqueous organocatalyst.