Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-chloro-4-Methoxy-1-isoquinolinyl)oxy]-, 1-(1,1-diMethylethyl) ester, (2S,4R)-
There total 10 articles about 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-chloro-4-Methoxy-1-isoquinolinyl)oxy]-, 1-(1,1-diMethylethyl) ester, (2S,4R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,7-dichloro-4-methoxyisoquinoline; (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;
With
potassium tert-butylate;
In
dimethyl sulfoxide;
at 36 ℃;
for 1h;
With
hydrogenchloride;
In
water; dimethyl sulfoxide; ethyl acetate;
at 11.2 - 14.6 ℃;
pH=4.82;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / 0.75 h / -78 - -65 °C
1.2: 1.17 h / -60 - 20 °C
1.3: 0 °C / pH 6
2.1: diazomethyl-trimethyl-silane / hexane; acetonitrile / 14 h / 0 - 20 °C
3.1: potassium tert-butylate / dimethyl sulfoxide / 10 - 20 °C
With
n-butyllithium; Triisopropyl borate; potassium tert-butylate; diazomethyl-trimethyl-silane;
In
tetrahydrofuran; hexane; dimethyl sulfoxide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diazomethyl-trimethyl-silane / hexane; acetonitrile / 14 h / 0 - 20 °C
2: potassium tert-butylate / dimethyl sulfoxide / 10 - 20 °C
With
potassium tert-butylate; diazomethyl-trimethyl-silane;
In
hexane; dimethyl sulfoxide; acetonitrile;
