TCS 21311

Base Information

Chemical Name:TCS 21311
CAS No.:1260181-14-3
Molecular Formula:C₂₇H₂₅F₃N₄O₄
Molecular Weight:526.515
Hs Code.:
Mol file:1260181-14-3.mol

Synonyms:TCS 21311;3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Suppliers and Price of TCS 21311

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TCS 21311
10mg
$ 573.00

Usbiological
TCS-21311
10mg
$ 460.00

TRC
TCS-21311
10mg
$ 160.00

Tocris
TCS21311 ≥98%(HPLC)
50
$ 1088.00

Tocris
TCS21311 ≥98%(HPLC)
10
$ 271.00

Sigma-Aldrich
JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
5mg
$ 246.00

Medical Isotopes, Inc.
TCS-21311
100 mg
$ 2200.00

CSNpharm
TCS21311
25mg
$ 432.00

CSNpharm
TCS21311
10mg
$ 204.00

CSNpharm
TCS21311
50mg
$ 820.00

Total 6 raw suppliers

Chemical Property of TCS 21311

Chemical Property:

Boiling Point:793.0±60.0 °C(Predicted)
PKA:7.91±0.60(Predicted)
PSA：109.23000
Density:1.436±0.06 g/cm3(Predicted)
LogP:3.45220
Storage Temp.:+2C to +8C
Solubility.:<52.65mg/ml in DMSO

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

TCS 21311 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A potent JAK3 inhibitor; selective for JAK3 over JAK1, JAK2 and TYK2. It also inhibits GSK-3β, PKCα and PKCθ.

Technology Process of TCS 21311

There total 5 articles about TCS 21311 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₇F₃N₄O₅

: 1260181-14-3
3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione

Guidance literature:: With sodium methylate; In methanol; at 25 ℃; for 0.5h;
DOI:10.1021/jm101157q

Reference yield:

: 239135-52-5
2-(5-fluoro-2-(trifluoromethyl)phenyl)acetic acid

: 1260181-14-3
3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 25 °C

1.2: 1 h / 25 °C

2.1: potassium tert-butylate / tetrahydrofuran / 2 h / 10 °C

2.2: 0.5 h / 85 °C

3.1: dimethyl sulfoxide / 1 h / 150 °C / Microwave irradiation

4.1: dmap / tetrahydrofuran / 2 h / 25 °C

5.1: sodium methylate / methanol / 0.5 h / 25 °C

With dmap; potassium tert-butylate; sodium methylate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm101157q

Reference yield:

: 1260181-10-9
3-(1H-indol-3-yl)-4-(5-piperazin-1-yl-2-trifluoromethylphenyl)pyrrole-2,5-dione

: 1260181-14-3
3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 2 h / 25 °C

2: sodium methylate / methanol / 0.5 h / 25 °C

With dmap; sodium methylate; In tetrahydrofuran; methanol;
DOI:10.1021/jm101157q