3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
• CAS No.: 1260181-07-4
• Molecular Formula: C₁₉H₁₀F₄N₂O₂
• Molecular Weight: 374.294

Synonyms:3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Chemical Property of 3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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Technology Process of 3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

There total 1 articles about 3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(3-indolyl)oxoacetic acid methyl ester (18372-22-0) + 2-(5-fluoro-2-(trifluoromethyl)phenyl)acetamide (1260181-08-5) → 3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione (1260181-07-4)

Guidance literature:

2-(3-indolyl)oxoacetic acid methyl ester; 2-(5-fluoro-2-(trifluoromethyl)phenyl)acetamide; With potassium tert-butylate; In tetrahydrofuran; at 10 ℃; for 2h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 85 ℃; for 0.5h;

DOI:10.1021/jm101157q

Reference yield: 97.0%

piperazine (110-85-0) + 3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione (1260181-07-4) → 3-(1H-indol-3-yl)-4-(5-piperazin-1-yl-2-trifluoromethylphenyl)pyrrole-2,5-dione (1260181-10-9)

Guidance literature:

In dimethyl sulfoxide; at 150 ℃; for 1h; Microwave irradiation;

DOI:10.1021/jm101157q

Reference yield: 66.0%

3-(5-fluoro-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione (1260181-07-4) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(3-(4-(1H-indole-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrole-3-yl)-4-(trifluoromethyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:

In dimethyl sulfoxide; at 150 ℃;

upstream raw materials:

2-(3-indolyl)oxoacetic acid methyl ester

2-(5-fluoro-2-(trifluoromethyl)phenyl)acetamide

Downstream raw materials:

3-(1H-indol-3-yl)-4-(5-morpholin-4-yl-2-trifluoromethylphenyl)pyrrole-2,5-dione

3-(1H-indol-3-yl)-4-(5-piperazin-1-yl-2-trifluoromethylphenyl)pyrrole-2,5-dione

4-{3-[4-(1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-4-trifluoromethylphenyl}piperazine-1-carbaldehyde

3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione

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