Chemical Property of N(4)-Hydroxycytidine
Chemical Property:
- Vapor Pressure:1.14E-15mmHg at 25°C
- Melting Point:169-172 °C(Solv: methanol (67-56-1))
- Boiling Point:576.1°Cat760mmHg
- PKA:8.19±0.20(Predicted)
- Flash Point:302.2°C
- PSA：137.07000
- Density:1.93g/cm3
- LogP:-2.27110
- Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
- Solubility.:Soluble in DMSO (up to 25 mg/ml) or in Water (up to 15 mg/ml with warming).
- XLogP3:-2.2
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:3
- Exact Mass:259.08043514
- Heavy Atom Count:18
- Complexity:398
- Purity/Quality:
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99%, *data from raw suppliers
EIDD1931 ≥98%(HPLC) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O
- Isomeric SMILES:C1=CN(C(=O)N=C1NO)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
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Description
EIDD-1931 is a ribonucleoside analog with antiviral activity. It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s =0.1, 0.15 and 0.3 μM, respectively). It also reduces viral titers of Venezuelan equine encephalitis virus (VEEV) TC-83 in infected Vero cells (EC50 = 0.426 μM) and wild-type and remdesivir-resistant strains of the model CoV mouse hepatitis virus (MHV) in infected DBT cells. EIDD-1931 (100 and 400 mg/kg twice per day) reduces lung viral titers in mouse models of respiratory syncytial virus (RSV) and H1N1 influenza A virus infection.
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Uses
EIDD 1931 is an orally bioavailable broad-spectrum antiviral that inhibits SARS-CoV-2 and other multiple endemic, epidemic and bat coronavirus and has the potential for seasonal and pandemic influenza treatment. A broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses.
