Hydroxy Saxagliptin

Base Information

• Chemical Name: Hydroxy Saxagliptin
• CAS No.: 841302-24-7
• Molecular Formula: C₁₈H₂₅N₃O₃
• Molecular Weight: 331.415
• Mol file: 841302-24-7.mol

Synonyms:Hydroxy Saxagliptin;(1S,3S,5S)-2-[(2S)-2-aMino-2-(3,5-dihydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-carbonitrile;BMS 510849;5-Hydroxy Saxagliptin;2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-aMino-2- (3,5-dihydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)-;(1S,3R,5S)-2-[(2S)-2-amino-2-[(3R,5S)-3,5-dihydroxy-1-adamantyl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile

Chemical Property of Hydroxy Saxagliptin

Chemical Property:

• Boiling Point: 589.2±45.0 °C(Predicted)
• PKA: 14.39±0.60(Predicted)
• PSA: 110.58000
• Density: 1.43±0.1 g/cm3(Predicted)
• LogP: 0.91108
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), DCM

Purity/Quality:

97% ^*data from raw suppliers

HydroxySaxagliptin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Saxagliptin (S143500). Hydroxy Saxagliptin is a metabolite of Saxagliptin (S143500).

Technology Process of Hydroxy Saxagliptin

There total 2 articles about Hydroxy Saxagliptin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

→ 5-hydroxy-saxagliptin (841302-24-7)

Guidance literature:

Reference yield:

saxagliptin (1564265-93-5) → 5-hydroxy-saxagliptin (841302-24-7) + C18H25N3O3

Guidance literature:

With sodium hypochlorite; octabromotetrakis(2,6-dichlorophenyl)porphyrin Fe(III)Cl; water; In acetonitrile; at 80 ℃; for 0.833333h; Microwave irradiation;

upstream raw materials:

saxagliptin

Refernces

• 1、 -. "ADAMANTYGLYCINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS". Page/Page column 52. . Retrieved 2008/06/13.