saxagliptin

Base Information

Chemical Name:saxagliptin
CAS No.:1564265-93-5
Molecular Formula:C₁₈H₂₅N₃O₂
Molecular Weight:315.415
Hs Code.:
Mol file:1564265-93-5.mol

Synonyms:

Suppliers and Price of saxagliptin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2’R,2S,cis)-Saxagliptin
25mg
$ 20740.00

Medical Isotopes, Inc.
(2??R,2S,cis)-Saxagliptin
25 mg
$ 20750.00

American Custom Chemicals Corporation
(1S,3S,5S,2R)-SAXAGLIPTIN 95.00%
5MG
$ 455.79

Total 10 raw suppliers

Chemical Property of saxagliptin

Chemical Property:

Boiling Point:548.7±35.0 °C(Predicted)
PKA:15.12±0.40(Predicted)
Density:1.35±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

(2’R,2S,cis)-Saxagliptin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2’R,2S,cis)-Saxagliptin is an impurity of Saxagliptin (S143500); a potent and selective reversible inhibitor of dipeptidyl peptidase-4 (DPP-IV) developed for the treatment of type 2 diabetes.

Technology Process of saxagliptin

There total 126 articles about saxagliptin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1564267-08-8
(R)-N-Boc-3-hydroxyadamantylglycine-L-trans-4,5-methanoprolinenitrile

: 1564265-98-0,1564265-93-5
(R)-3-hydroxyadamantylglycine-L-trans-4,5-methanoprolinenitrile

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 65 ℃; for 1.5h;
DOI:10.1016/j.bmc.2013.12.061

Reference yield:

: saxaglipitin

: 361442-04-8,1564265-93-5
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)-1-oxoethyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile

Guidance literature:: With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 1h; pH=9;

Reference yield:

: [(1S)-2-[(1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-oxoethyl]carbamic acid-1,1-dimethylethyl ester

: 361442-04-8,1564265-93-5
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)-1-oxoethyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile

Guidance literature:: [(1S)-2-[(1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-oxoethyl]carbamic acid-1,1-dimethylethyl ester; With hydrogenchloride; water; In methanol; dichloromethane; at 0 - 20 ℃; for 20.6667h;

With sodium hydroxide; In water; pH=> 11;