2-(4-Bromophenyl)quinoline-4-carbohydrazide

Base Information

• Chemical Name: 2-(4-Bromophenyl)quinoline-4-carbohydrazide
• CAS No.: 351899-02-0
• Molecular Formula: C16H12BrN3O
• Molecular Weight: 342.195
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID80373749
• Wikidata: Q82162074
• Mol file: 351899-02-0.mol

Synonyms:2-(4-bromophenyl)quinoline-4-carbohydrazide;351899-02-0;2-(4-bromo-phenyl)-quinoline-4-carboxylic acidhydrazide;2-(4-Bromo-phenyl)-quinoline-4-carboxylic acid hydrazide;2-(4-bromophenyl)quinoline-4-carboxylic acidhydrazide;2-(4-bromophenyl)quinoline-4-carboxylic acid hydrazide;DTXSID80373749;BBL016585;MFCD01421812;STK424645;AKOS003245405;SB86228;VS-05387;FT-0748683;A912468

Chemical Property of 2-(4-Bromophenyl)quinoline-4-carbohydrazide

Chemical Property:

• PSA: 68.01000
• LogP: 4.35900
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 341.01637
• Heavy Atom Count: 21
• Complexity: 371

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Bromophenyl)quinoline-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CC(=N2)C3=CC=C(C=C3)Br)C(=O)NN

Technology Process of 2-(4-Bromophenyl)quinoline-4-carbohydrazide

There total 4 articles about 2-(4-Bromophenyl)quinoline-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4'-bromophenyl)-quinoline-4-carboxylate (351982-02-0) → 2-(4-bromophenyl)quinoline-4-carboxylic acid hydrazide (351899-02-0)

Guidance literature:

With hydrazine hydrate;

DOI:10.1002/ardp.19362740405

Reference yield:

2-(4'-bromophenyl)quinoline-4-carboxylic acid (103914-52-9) → 2-(4-bromophenyl)quinoline-4-carboxylic acid hydrazide (351899-02-0)

Guidance literature:

Multi-step reaction with 2 steps

2: N₂H₄+H₂O

With hydrazine hydrate;

DOI:10.1002/ardp.19362740405

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 2-(4-bromophenyl)quinoline-4-carboxylic acid hydrazide (351899-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanolic KOH

3: N₂H₄+H₂O

With potassium hydroxide; hydrazine hydrate;

DOI:10.1002/ardp.19362740405

upstream raw materials:

ethyl 2-(4'-bromophenyl)-quinoline-4-carboxylate

2-(4'-bromophenyl)quinoline-4-carboxylic acid

indole-2,3-dione

para-bromoacetophenone

Downstream raw materials:

2-(4-bromo-phenyl)-quinoline-4-carbonyl azide