351982-02-0

Upstream product

• 103914-52-9 2-(4'-bromophenyl)quinoline-4-carboxylic acid 
• 97-64-3 ethyl 2-hydroxypropionate 
• 1122-91-4 4-bromo-benzaldehyde 
• 62-53-3 aniline 
• 64-17-5 ethanol 
• 99-90-1 para-bromoacetophenone 
• 91-56-5 indole-2,3-dione 
• 36997-05-4 2-methoxyacrylic acid ethyl ester 
• 1613-97-4 (E)-1-(4-bromophenyl)-N-phenylmethanimine 

Downstream Products

• 856086-95-8 [2-(4-bromo-phenyl)-[4]quinolyl]-carbamic acid ethyl ester 
• 859929-64-9 2-(4-bromo-phenyl)-quinoline-4-carbonyl azide 
• 345902-20-7 4-amino-2-(4'-bromophenyl)quinoline 
• 351899-02-0 2-(4-bromophenyl)quinoline-4-carboxylic acid hydrazide 
• 19155-99-8 [6,8-dichloro-2-(4-chloro-phenyl)-[4]quinolyl]-[2]piperidyl-methanol 

Relevant academic research and scientific papers

Ethyl lactate-involved three-component dehydrogenative reactions: Biomass feedstock in diversity-oriented quinoline synthesis

Three-component reactions of ethyl/methyl lactate, anilines and aldehydes providing quinolines have been developed via simple iron(iii) chloride catalysis without using an additional organic medium or external oxidant. This three-component protocol shows

New quinoline-based heterocycles as anticancer agents targeting Bcl-2

The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (ABT-19

Rapid synthesis of quinoline-4-carboxylic acid derivatives from arylimines and 2-substituted acrylates or acrylamides under indium(III) chloride and microwave activations. Scope and limitations of the reaction

Rapid synthesis of quinoline-4-carboxylic acid derivatives has been achieved by reaction of 2-methoxy acrylates or acrylamides with N-arylbenzaldimines in acetonitrile under InCl3 catalysis and microwave irradiation. Isolated yields up to 57% within 3 min have been obtained. The Lewis acid and the microwave activation appeared as crucial parameters for the reaction. The role of indium chloride and ytterbium triflate was specified using 13C NMR data and model theoretical studies. The Royal Society of Chemistry 2005.