1-(3-Methoxyphenyl)urea

Base Information

• Chemical Name: 1-(3-Methoxyphenyl)urea
• CAS No.: 139-77-5
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2924299090
• European Community (EC) Number: 683-589-2
• NSC Number: 526659
• UNII: J9X6PPO2IH
• DSSTox Substance ID: DTXSID80160858
• Nikkaji Number: J2.968.397B
• Wikidata: Q72518045
• Mol file: 139-77-5.mol

Synonyms:1-(3-methoxyphenyl)urea;139-77-5;(3-Methoxyphenyl)urea;N-(3-Methoxyphenyl)urea;Urea, (m-methoxyphenyl)-;(m-Methoxyphenyl)urea;m-Anisylurea;3-methoxyphenylurea;3-Ureidoanisole;Urea, (3-methoxyphenyl)-;J9X6PPO2IH;NSC 526659;BRN 2641163;NSC-526659;G 5;Urea,N-(3-methoxyphenyl)-;Maybridge4_001921;UNII-J9X6PPO2IH;3-(3-methoxyphenyl)urea;Oprea1_236753;SCHEMBL166106;DTXSID80160858;HMS1526H07;AMY10463;CCG-41941;MFCD00025423;NSC526659;STL141106;UREA, N-(3-METHOXYPHENYL)-;AKOS000113526;NCGC00177116-01;3-(Carbamoylamino)anisole, 3-Ureidoanisole;LS-160426;CS-0315168;FT-0631811;L10046;2X-0019;A885948;J-503160;SR-01000631982-1;BRD-K80985359-001-01-5

Chemical Property of 1-(3-Methoxyphenyl)urea

Chemical Property:

• Vapor Pressure: 0.00391mmHg at 25°C
• Melting Point: 138-139°C
• Refractive Index: 1.606
• Boiling Point: 279.9 °C at 760 mmHg
• Flash Point: 123.1 °C
• PSA: 64.35000
• Density: 1.243g/cm³
• LogP: 1.95910
• Storage Temp.: -20°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 161

Purity/Quality:

97% ^*data from raw suppliers

N-(3-methoxyphenyl)urea ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)NC(=O)N

Technology Process of 1-(3-Methoxyphenyl)urea

There total 9 articles about 1-(3-Methoxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

potassium cyanide (151-50-8) + m-Anisidine (536-90-3,918666-97-4) → 1-(3-methoxyphenyl)urea (139-77-5)

Guidance literature:

With hydrogenchloride; In water; for 2h; Ambient temperature;

Reference yield: 87.0%

m-Anisidine (536-90-3,918666-97-4) + urea (57-13-6) → 1-(3-methoxyphenyl)urea (139-77-5)

Guidance literature:

urea; With mannitol; citric acid; at 80 ℃;

m-Anisidine; With iodine; at 80 ℃; for 13h;

DOI:10.1080/00304948.2014.944408

Reference yield: 78.0%

sodium isocyanate (917-61-3) + m-Anisidine (536-90-3,918666-97-4) → 1-(3-methoxyphenyl)urea (139-77-5)

Guidance literature:

With acetic acid; at 20 - 40 ℃;

DOI:10.1039/b105420c

upstream raw materials:

potassium cyanide

m-Anisidine

sodium isocyanate

1-chloro-3-methoxy-benzene

Downstream raw materials:

1-(3-methoxyphenyl)-3-phenylacetylurea

m-Anisidine

1-formyl-3-(3-methoxyphenyl)urea

6-methoxy-N-(3-methoxyphenyl)-3-oxo-1,3-dihydroisobenzofuran-1-carboxamide