TERT-BUTYL 4-CYANO-4-(4-METHOXYPHENYL)PIPERIDINE-1-CARBOXYLATE

Base Information

Chemical Name:TERT-BUTYL 4-CYANO-4-(4-METHOXYPHENYL)PIPERIDINE-1-CARBOXYLATE
CAS No.:553631-38-2
Molecular Formula:C18H24N2O3
Molecular Weight:316.4
Hs Code.:
Mol file:553631-38-2.mol

Synonyms:TERT-BUTYL 4-CYANO-4-(4-METHOXYPHENYL)PIPERIDINE-1-CARBOXYLATE;1-Boc-4-cyano-4-(4-methoxyphenyl)-piperidine

Suppliers and Price of TERT-BUTYL 4-CYANO-4-(4-METHOXYPHENYL)PIPERIDINE-1-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
1-Boc-4-cyano-4-(4-methoxyphenyl)-piperidine 97%
0.25g
$ 110.00

Acrotein
1-Boc-4-cyano-4-(4-methoxyphenyl)-piperidine 97%
5g
$ 889.17

ACHEMBLOCK
1-Boc-4-cyano-4-(4-methoxyphenyl)-piperidine 95%
250MG
$ 135.00

Total 2 raw suppliers

Chemical Property of TERT-BUTYL 4-CYANO-4-(4-METHOXYPHENYL)PIPERIDINE-1-CARBOXYLATE

Chemical Property:

PSA：62.56000
LogP:3.42538

Purity/Quality:

95%-98% ^*data from raw suppliers

1-Boc-4-cyano-4-(4-methoxyphenyl)-piperidine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-CYANO-4-(4-METHOXYPHENYL)PIPERIDINE-1-CARBOXYLATE

There total 3 articles about TERT-BUTYL 4-CYANO-4-(4-METHOXYPHENYL)PIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 104-47-2
p-methoxybenzylnitrile

: 118753-70-1
N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

: 553631-38-2
tert-butyl 4-cyano-4-(4-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 60 ℃; for 17h;
DOI:10.1016/j.ejmech.2017.06.067

Reference yield: 61.0%

: 553631-38-2
tert-butyl 4-cyano-4-(4-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 60 ℃; for 16h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 553631-38-2
tert-butyl 4-cyano-4-(4-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane / 0.17 h / 0 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 17 h / 0 - 60 °C

With sodium hydride; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2017.06.067