1-Boc-4-(4-Methoxyphenyl)-4-piperidinecarboxylic acid

Base Information

• Chemical Name: 1-Boc-4-(4-Methoxyphenyl)-4-piperidinecarboxylic acid
• CAS No.: 1158750-72-1
• Molecular Formula: C₁₈H₂₅NO₅
• Molecular Weight: 335.4
• Hs Code.: 2933399990
• Mol file: 1158750-72-1.mol

Synonyms:

Chemical Property of 1-Boc-4-(4-Methoxyphenyl)-4-piperidinecarboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-Boc-4-(4-methoxyphenyl)-4-carboxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Boc-4-(4-Methoxyphenyl)-4-piperidinecarboxylic acid

There total 4 articles about 1-Boc-4-(4-Methoxyphenyl)-4-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

tert-butyl 4-cyano-4-(4-methoxyphenyl)piperidine-1-carboxylate (553631-38-2) → 1-(tert-butoxycarbonyl)-4-(4-methoxyphenyl)piperidine-4-carboxylic acid (1158750-72-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 48h; Reflux;

DOI:10.1016/j.ejmech.2017.06.067

Reference yield: 57.0%

→ 1-(tert-butoxycarbonyl)-4-(4-methoxyphenyl)piperidine-4-carboxylic acid (1158750-72-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 48h; Reflux;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1-(tert-butoxycarbonyl)-4-(4-methoxyphenyl)piperidine-4-carboxylic acid (1158750-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / dichloromethane / 0.17 h / 0 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 17 h / 0 - 60 °C

3: sodium hydroxide; water / ethanol / 48 h / Reflux

With water; sodium hydride; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.ejmech.2017.06.067

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl 4-cyano-4-(4-methoxyphenyl)piperidine-1-carboxylate

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

Refernces

• 1、 -. "A nitrogen-containing heterocyclic phenyl piperidine compound and its preparation method and application". Paragraph 0075-0078; 0081. . Retrieved 2017/09/01.