3,5-Dibromopyridine-2,6-diamine

Base Information

• Chemical Name: 3,5-Dibromopyridine-2,6-diamine
• CAS No.: 76942-20-6
• Molecular Formula: C₅H₅Br₂N₃
• Molecular Weight: 266.923
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID80362855
• Wikidata: Q82146336
• Mol file: 76942-20-6.mol

Synonyms:3,5-dibromopyridine-2,6-diamine;76942-20-6;2,6-Diamine-3,5-dibromopyridine;3,5-dibromo-6-imino-1,6-dihydropyridin-2-amine;2,6-Diamino-3,5-dibromopyridine;DTXSID80362855;2,3-diamino-3,5-dibromopyridine;AMY31747;BDA94220;MFCD04113795;AKOS000267436;AKOS037645405;AS-60663;CS-0060149;FT-0747490;W18211

Chemical Property of 3,5-Dibromopyridine-2,6-diamine

Chemical Property:

• PSA: 65.66000
• LogP: 2.28230
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 266.88297
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

95% ^*data from raw suppliers

2,6-dibromopyridine-3,5-diamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=NC(=C1Br)N)N)Br

Technology Process of 3,5-Dibromopyridine-2,6-diamine

There total 1 articles about 3,5-Dibromopyridine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2.6-diaminopyridine (141-86-6) → 2,6-diamino-3,5-dibromopyridine (76942-20-6)

Guidance literature:

With bromine; acetic acid; at 0 - 20 ℃; for 5h;

DOI:10.1002/ejoc.201403035

Reference yield: 47.0%

dimethyl 5-(pinacolboryl)isophthalate (944392-68-1) + 2,6-diamino-3,5-dibromopyridine (76942-20-6) → C25H23N3O8

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; for 72h; Inert atmosphere; Reflux;

DOI:10.1039/c8dt02686f

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) + 2,6-diamino-3,5-dibromopyridine (76942-20-6) → C19H19N3O2

Guidance literature:

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In acetonitrile; at 110 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01293

upstream raw materials:

2.6-diaminopyridine

Downstream raw materials:

2,3,5,6-tetrabromopyridine