(4S,4'S)- 2,2'-(1-ethylpropylidene)bis[4,5-dihydro-4-phenyl-Oxazole

Base Information

• Chemical Name: (4S,4'S)- 2,2'-(1-ethylpropylidene)bis[4,5-dihydro-4-phenyl-Oxazole
• CAS No.: 190791-28-7
• Molecular Formula: C23H26N2O2
• Molecular Weight: 362.46
• Hs Code.: 29349990
• Mol file: 190791-28-7.mol

Synonyms:(4S,4'S)- 2,2'-(1-ethylpropylidene)bis[4,5-dihydro-4-phenyl-Oxazole

Chemical Property of (4S,4'S)- 2,2'-(1-ethylpropylidene)bis[4,5-dihydro-4-phenyl-Oxazole

Chemical Property:

• PSA: 43.18000
• LogP: 4.00400

Purity/Quality:

97% ^*data from raw suppliers

(4S,4'S)-2,2'-(Pentane-3,3-diyl)bis(4-phenyl-4,5-dihydrooxazole) 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

Technology Process of (4S,4'S)- 2,2'-(1-ethylpropylidene)bis[4,5-dihydro-4-phenyl-Oxazole

There total 6 articles about (4S,4'S)- 2,2'-(1-ethylpropylidene)bis[4,5-dihydro-4-phenyl-Oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N1,N3-bis((R)-2-hydroxy-1-phenylethyl)-2,2-diethylmalonamide → (R)-4-phenyl-2-(3-((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pentane-3-yl)-4,5-dihydrooxazole (190791-28-7,195515-48-1)

Guidance literature:

N¹,N³-bis((R)-2-hydroxy-1-phenylethyl)-2,2-diethylmalonamide; With thionyl chloride; In chloroform; at 0 - 70 ℃; for 4h;

With potassium hydroxide; In methanol; for 4h; Reflux;

DOI:10.1021/acs.orglett.5b00131

Reference yield:

N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide (195515-46-9) → (R)-4-phenyl-2-(3-((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pentane-3-yl)-4,5-dihydrooxazole (190791-28-7,195515-48-1)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1039/a702920i

Reference yield:

N-[(1R)-2-chloro-1-phenylethyl]-2-ethyl-2-[(4R)-4-phenyl-4,5-dihydrooxazol-2-yl]butyramide → (R)-4-phenyl-2-(3-((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pentane-3-yl)-4,5-dihydrooxazole (190791-28-7,195515-48-1)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1039/a702920i

upstream raw materials:

N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide

diethyl diethylmalonate

diethyl malonic acid

diethylmalonyl chloride