N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide

Base Information

• Chemical Name: N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide
• CAS No.: 195515-46-9
• Molecular Formula: C₂₃H₂₈Cl₂N₂O₂
• Molecular Weight: 435.394
• Mol file: 195515-46-9.mol

Synonyms:N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide

Chemical Property of N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide

There total 1 articles about N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N1,N3-bis((R)-2-hydroxy-1-phenylethyl)-2,2-diethylmalonamide → N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide (195515-46-9)

Guidance literature:

With thionyl chloride; for 4h; Heating;

DOI:10.1016/S0957-4166(01)00559-6

Reference yield: 83.0%

N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide (195515-46-9) → N-[(1R)-2-chloro-1-phenylethyl]-2-ethyl-2-[(4R)-4-phenyl-4,5-dihydrooxazol-2-yl]butyramide

Guidance literature:

With sodium hydroxide; In methanol; water; at 50 ℃; for 1h;

DOI:10.1016/S0957-4166(01)00559-6

Reference yield:

N,N'-Bis[(1R)-2-chloro-1-phenylethyl]-2,2-diethyl-1,3-propanediamide (195515-46-9) → (R)-4-phenyl-2-(3-((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pentane-3-yl)-4,5-dihydrooxazole (190791-28-7,195515-48-1)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1039/a702920i

Downstream raw materials:

(R)-4-phenyl-2-(3-((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pentane-3-yl)-4,5-dihydrooxazole