4-((4-Methylpiperazin-1-yl)Methyl)phenol

Base Information

• Chemical Name: 4-((4-Methylpiperazin-1-yl)Methyl)phenol
• CAS No.: 80166-00-3
• Molecular Formula: C12H18N2O
• Molecular Weight: 206.288
• Mol file: 80166-00-3.mol

Synonyms:4-((4-Methylpiperazin-1-yl)Methyl)phenol;4-[(4-methyl-1-piperazinyl)methyl]phenol

Chemical Property of 4-((4-Methylpiperazin-1-yl)Methyl)phenol

Chemical Property:

• Melting Point: 176 - 181 °C (ethyl acetate)
• PSA: 26.71000
• LogP: 1.01540

Purity/Quality:

99% ^*data from raw suppliers

4-((4-Methylpiperazin-1-yl)methyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-((4-Methylpiperazin-1-yl)Methyl)phenol

There total 4 articles about 4-((4-Methylpiperazin-1-yl)Methyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-[(4-methyl-1-piperazinyl)methyl]aniline (70261-82-4) → 4-[(4-methylpiperazin-1-yl)methyl]phenol (80166-00-3)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 0 - 85 ℃; for 0.5h;

Reference yield:

1-methyl-piperazine (109-01-3) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-[(4-methylpiperazin-1-yl)methyl]phenol (80166-00-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.5b01654

Reference yield:

4-nitrobenzyl chloride (100-14-1) → 4-[(4-methylpiperazin-1-yl)methyl]phenol (80166-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / K₂CO₃ / acetone / 46 h / Heating

2: 85 percent / Fe, 10percent FeCl₃ / aq. ethanol / 15 h / Heating

3: 76 percent / 1M H₂SO₄, NaNO₂ / H₂O / 0.5 h / 0 - 85 °C

With sulfuric acid; iron(III) chloride; iron; potassium carbonate; sodium nitrite; In ethanol; water; acetone;

upstream raw materials:

4-[(4-methyl-1-piperazinyl)methyl]aniline

4-nitrobenzyl chloride

4-(4-nitrobenzyl)-1-methylpiperazine

1-methyl-piperazine

Downstream raw materials:

2-[4-(4-Methyl-piperazin-1-ylmethyl)-phenoxy]-propionic acid ethyl ester

2,3-diamino-N₂-(2-(4-((4-methylpiperazin-1-yl)methyl)phenoxy)ethyl)quinoxaline

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