(4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER

Base Information

• Chemical Name: (4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER
• CAS No.: 66405-41-2
• Molecular Formula: C9H14O3
• Molecular Weight: 170.208
• Hs Code.: 2918300090
• Mol file: 66405-41-2.mol

Synonyms:(4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER;(4-OXOCYCLOHEXYL)ACETIC ACID;Cyclohexaneacetic acid, 4-oxo-, Methyl ester;Methyl (4-oxocyclohexyl)acetate

Chemical Property of (4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0252mmHg at 25°C
• Boiling Point: 247.8°C at 760 mmHg
• Flash Point: 103.2°C
• PSA: 43.37000
• Density: 1.06g/cm³
• LogP: 1.30880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(4-Oxocyclohexyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER

There total 9 articles about (4-OXO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate (317338-46-8) → (4-oxo-cyclohexyl)-acetic acid methyl ester (66405-41-2)

Guidance literature:

With hydrogenchloride; In water; acetone; at 20 ℃; for 15h;

Reference yield: 97.4%

Methyl 4-hydroxyphenylacetate (14199-15-6) → (4-oxo-cyclohexyl)-acetic acid methyl ester (66405-41-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In o-xylene; at 140 ℃; for 7 - 8h; under 5688.78 - 5947.36 Torr;

Reference yield: 89.0%

8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane (172270-85-8) → (4-oxo-cyclohexyl)-acetic acid methyl ester (66405-41-2)

Guidance literature:

8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane; With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 8h;

With sulfuric acid; In methanol; water; at 20 ℃; for 4h;

DOI:10.1002/anie.201706018

upstream raw materials:

4-(Carbomethoxymethylene)cyclohexanone

Methyl 4-hydroxyphenylacetate

1,4-Cyclohexanedione

methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate

Downstream raw materials:

<4-Methyl-cyclohexen-(3)-yl>-essigsaeure-methylester

methyl (4-propylidenecyclohexyl)acetate

{4-[bis-(4-hydroxy-phenyl)-methylene]-cyclohexyl}-acetic acid methyl ester

4-ethyl[bis(4-methoxymethoxyphenyl)methylene]cyclohexane