(1,4-Dioxa-spiro[4.5]dec-8-YL)-acetic acid Methyl ester

Base Information

• Chemical Name: (1,4-Dioxa-spiro[4.5]dec-8-YL)-acetic acid Methyl ester
• CAS No.: 317338-46-8
• Molecular Formula: C11H18O4
• Molecular Weight: 214.262
• Hs Code.: 2932999099
• Mol file: 317338-46-8.mol

Synonyms:(1,4-dioxa-spiro[4.5]dec-8-yl)-acetic acid methyl ester;methyl 1,4-dioxaspiro[4.5]decane-8-acetate;methyl 2-(1,4-dioxaspiro[4.5]dec-8-yl)acetate;

Chemical Property of (1,4-Dioxa-spiro[4.5]dec-8-YL)-acetic acid Methyl ester

Chemical Property:

• Boiling Point: 292.1±15.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 1.48280
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1,4-Dioxa-spiro[4.5]dec-8-YL)-acetic acid Methyl ester

There total 5 articles about (1,4-Dioxa-spiro[4.5]dec-8-YL)-acetic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane (172270-85-8) → methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate (317338-46-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate;

DOI:10.1016/j.bmcl.2009.01.058

Reference yield: 95.0%

→ methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate (317338-46-8)

Guidance literature:

Reference yield: 45.0%

methanol (67-56-1) + 1-(4-hydroxy-2,3,5,6-tetramethylphenyl)-2-(1,4-dioxaspiro[4.5]decan-8-yl)ethan-1-one → methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate (317338-46-8)

Guidance literature:

With ammonium cerium (IV) nitrate; at 25 ℃;

DOI:10.1055/s-0040-1707289

upstream raw materials:

8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane

cyclohexanedione monoethylene ketal

methanol

Downstream raw materials:

2-(1,4-dioxaspiro[4.5]decan-8-yl)ethanol

methyl 2-((1r,4r)-4-hydroxycyclohexyl)acetate

1-(3,3-dicyano-6,6,6-trifluorohexyl)-4-ethynyl-4-hydroxycyclohexane

1-(3,3-dicyano-6,6,6-trifluorohexyl)-4-ethynyl-4-fluorocyclohexane