2-[(Trimethylgermyl)methyl]pyridine

Base Information

• Chemical Name: 2-[(Trimethylgermyl)methyl]pyridine
• CAS No.: 31590-87-1
• Molecular Formula: C₉H₁₅GeN
• Molecular Weight: 209.815
• Hs Code.: 2933399090
• Mol file: 31590-87-1.mol

Synonyms:2-[(Trimethylgermyl)methyl]pyridine

Chemical Property of 2-[(Trimethylgermyl)methyl]pyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.76790

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(Trimethylgermyl)methyl]pyridine

There total 2 articles about 2-[(Trimethylgermyl)methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

α-picoline (109-06-8) + chlorotrimethylgermane (1529-47-1) + methyllithium (917-54-4) → (2-Pyridylmethyl)-trimethylgermanium (31590-87-1)

Guidance literature:

In diethyl ether; (N2); addn. of 1 equiv. of MeLi to soln. of 2-methylpyridine in ether; reflux for 30 min; cooling to room temp.; stirring for 1 h; cooling to -78°C; addn. of Me3GeCl (1.2 equiv.); stirring at room temp. for 1 h; quenching with H2O; extn. into ether; washing with NaOH; washing of ether layer with H2O; drying (MgSO4); removal of solvent under reduced pressure; dry-flash chromy. (petroleum spirits/ether);

DOI:10.1021/om900681m

Reference yield:

→ (2-Pyridylmethyl)-trimethylgermanium (31590-87-1)

Guidance literature:

2-Pyridylmethyl-Li, Me3GeCl;

DOI:10.1016/S0022-328X(00)80650-6

upstream raw materials:

α-picoline

chlorotrimethylgermane

methyllithium

Refernces