7-DesMethyl-3-hydroxyagoMelatine

Base Information

• Chemical Name: 7-DesMethyl-3-hydroxyagoMelatine
• CAS No.: 166527-00-0
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245.278
• Mol file: 166527-00-0.mol

Synonyms:7-DesMethyl-3-hydroxyagoMelatine

Chemical Property of 7-DesMethyl-3-hydroxyagoMelatine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

7-Desmethyl-3-hydroxyagomelatine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 7-Desmethyl-3-hydroxyagomelatine is a 1-(aminoethyl)naphthalene derivative with potential binding affinity for melatonin receptors.

Technology Process of 7-DesMethyl-3-hydroxyagoMelatine

There total 2 articles about 7-DesMethyl-3-hydroxyagoMelatine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide (166526-99-4) → N-[2-(3,7-dihydroxy-1-naphthyl)ethyl]acetamide (166527-00-0)

Guidance literature:

With sodium hydroxide; boron tribromide; In dichloromethane;

Reference yield:

agomelatine (138112-76-2) → N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide (152302-45-9) + 1'-Hydroxy-Agomelatine + N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide (166526-99-4) + N-[2-(3,7-dihydroxy-1-naphthyl)ethyl]acetamide (166527-00-0)

Guidance literature:

With human liver cytochrome P₄₅₀; In methanol; acetate buffer; at 37 ℃; pH=8; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1016/S0928-0987(00)00146-9

upstream raw materials:

agomelatine

N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide