2-fluorodopa

Base Information

• Chemical Name: 2-fluorodopa
• CAS No.: 107597-46-6
• Molecular Formula: C₉H₁₀FNO₄
• Molecular Weight: 215.181
• Mol file: 107597-46-6.mol

Synonyms:2-fluorodopa

Chemical Property of 2-fluorodopa

Chemical Property:

• Vapor Pressure: 3.21E-08mmHg at 25°C
• Boiling Point: 431.7°C at 760 mmHg
• Flash Point: 214.9°C
• Density: 1.553g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluorodopa

There total 5 articles about 2-fluorodopa which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-fluoro-L-3,4-dimethoxyphenylalanine (476359-40-7) → 2-fluoro-L-3,4-dihydroxyphenylalanine (107597-46-6)

Guidance literature:

With hydrogen bromide; at 145 ℃; for 1h;

DOI:10.1016/S0957-4166(02)00321-X

Reference yield:

acetylamino-(2-fluoro-3,4-dimethoxy-benzyl)-malonic acid diethyl ester (858-61-7) → 2-fluoro-3,4-dihydroxy-phenylalanine (102129-95-3,107597-46-6)

Guidance literature:

With hydrogen bromide;

Reference yield:

α-chloro-2-fluoro-3,4-dimethoxytoluene (1716-43-4) → 2-fluoro-L-3,4-dihydroxyphenylalanine (107597-46-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / K₂CO₃; Bu₄NBr / acetonitrile / 50 °C

2: 83 percent / aq. HCl / CH₂Cl₂ / 20 °C

3: 80 percent / aq. LiOH / tetrahydrofuran / 2 h / 0 °C

4: 70 percent / aq. HBr / 1 h / 145 °C

With hydrogenchloride; lithium hydroxide; tetrabutylammomium bromide; hydrogen bromide; potassium carbonate; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/S0957-4166(02)00321-X

upstream raw materials:

acetylamino-(2-fluoro-3,4-dimethoxy-benzyl)-malonic acid diethyl ester

2-fluoro-L-3,4-dimethoxyphenylalanine

α-chloro-2-fluoro-3,4-dimethoxytoluene

(2R)-N-[(2S)-2-amino-2-(2'-fluoro-3',4'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

Refernces