4-Piperidineacetic acid, 4-carboxy-1-(phenylMethyl)-, (Hydrochloride) (1:1)

Base Information

• Chemical Name: 4-Piperidineacetic acid, 4-carboxy-1-(phenylMethyl)-, (Hydrochloride) (1:1)
• CAS No.: 40117-95-1
• Molecular Formula: C15H20ClNO4
• Molecular Weight: 313.7766
• Mol file: 40117-95-1.mol

Synonyms:4-Piperidineacetic acid, 4-carboxy-1-(phenylMethyl)-, (Hydrochloride) (1:1)

Chemical Property of 4-Piperidineacetic acid, 4-carboxy-1-(phenylMethyl)-, (Hydrochloride) (1:1)

Chemical Property:

• PSA: 77.84000
• LogP: 2.56800

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Piperidineaceticacid,4-carboxy-1-(phenylmethyl)-,(Hydrochloride)1:1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Piperidineacetic acid, 4-carboxy-1-(phenylMethyl)-, (Hydrochloride) (1:1)

There total 5 articles about 4-Piperidineacetic acid, 4-carboxy-1-(phenylMethyl)-, (Hydrochloride) (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-benzyl-4-cyanomethylpiperidine-4-carbonitrile (86945-27-9) → 1-Benzyl-4-(carboxymethyl)-4-piperidinecarboxylic acid hydrochloride (40117-95-1)

Guidance literature:

With hydrogenchloride; for 72h; Heating;

DOI:10.1021/jm030354b

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 1-Benzyl-4-(carboxymethyl)-4-piperidinecarboxylic acid hydrochloride (40117-95-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N; molecular sieves 4A / CH₂Cl₂ / 20 °C

2: 55.10 g / ethanol; H₂O / 2 h / Heating

3: 98 percent / aq. HCl / 72 h / Heating

With hydrogenchloride; 4 A molecular sieve; triethylamine; In ethanol; dichloromethane; water; 1: Knoevenagel condensation;

DOI:10.1021/jm030354b

Reference yield:

ethyl 2-(1-benzylpiperidin-4-ylidene)-2-cyanoacetate (1463-52-1) → 1-Benzyl-4-(carboxymethyl)-4-piperidinecarboxylic acid hydrochloride (40117-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 55.10 g / ethanol; H₂O / 2 h / Heating

2: 98 percent / aq. HCl / 72 h / Heating

With hydrogenchloride; In ethanol; water;

DOI:10.1021/jm030354b

upstream raw materials:

<4-ethoxycarbonyl-1-(phenylmethyl)piperidin-4-yl>acetic acid ethyl ester

1-benzyl-4-cyanomethylpiperidine-4-carbonitrile

1-phenylmethyl-4-piperidone

ethyl 2-(1-benzylpiperidin-4-ylidene)-2-cyanoacetate

Downstream raw materials:

8-benzyl-8-aza-2-oxaspiro<4.5>decan-1-one

8-benzyl-2-(2-propyl)-2,8-diazaspiro<4,5>decane-1,3-dione

4-(3-oxo-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile

4-(1-oxo-2,8-diazaspiro[4.5]dec-2-yl)benzonitrile