N-butyl-3,4,5-trimethoxybenzamide

Base Information

• Chemical Name: N-butyl-3,4,5-trimethoxybenzamide
• CAS No.: 70001-46-6
• Molecular Formula: C14H21 N O4
• Molecular Weight: 267.325
• Mol file: 70001-46-6.mol

Synonyms:N-Butyl-3,4,5-trimethoxybenzamide

Chemical Property of N-butyl-3,4,5-trimethoxybenzamide

Chemical Property:

• Vapor Pressure: 4.4E-05mmHg at 25°C
• Boiling Point: 350.4°Cat760mmHg
• Flash Point: 165.7°C
• Density: 1.063g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-butyl-3,4,5-trimethoxybenzamide

There total 2 articles about N-butyl-3,4,5-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + N-butylamine (109-73-9,85404-21-3) → N-butyl-3,4,5-trimethoxybenzamide (70001-46-6)

Guidance literature:

N-butylamine; With carbon dioxide; Green chemistry;

3,4,5-trimethoxy-benzaldehyde; With tert.-butylhydroperoxide; iron(II) chloride tetrahydrate; tetrabutylammomium bromide; In water; acetonitrile; at 40 ℃; for 10h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Inert atmosphere; Green chemistry;

DOI:10.1016/j.tetlet.2015.08.066

Reference yield:

→ N-butyl-3,4,5-trimethoxybenzamide (70001-46-6)

Guidance literature:

/BRN= 2945068/;

DOI:10.1021/ja01525a042

Reference yield:

N-butyl-3,4,5-trimethoxybenzamide (70001-46-6) + 2-Amino-3-ethoxycarbonyl-5-methyl-4,5,6,7-tetrahydrobenzothiophene (70733-08-3) → 3-Butyl-6-methyl-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (845520-99-2)

Guidance literature:

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

N-butylamine

Downstream raw materials:

3-Butyl-6-methyl-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one