DPO-1

Base Information

• Chemical Name: DPO-1
• CAS No.: 43077-30-1
• Molecular Formula: C22H29OP
• Molecular Weight: 340.445
• Hs Code.: 2902909090
• Mol file: 43077-30-1.mol

Synonyms:DPO-1;[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphineoxide;(+)-Neomenthyl diphenylphosphine oxide;(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide

Chemical Property of DPO-1

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 434.966°C at 760 mmHg
• Flash Point: 216.86°C
• PSA: 26.88000
• Density: 1.054g/cm³
• LogP: 5.46130
• Storage Temp.: Store at +4°C
• Solubility.: DMSO: soluble2mg/mL, clear (warmed)

Purity/Quality:

97% ^*data from raw suppliers

DPO-1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DPO-1

There total 15 articles about DPO-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(1R,2S,5R)-menthyl chloride (16052-42-9) + sodium diphenylphosphide (4376-01-6) → ((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-diphenyl-phosphane (43077-29-8,32511-22-1) + neomenthyldiphenylphosphine oxide (43077-30-1) + diphenylphosphane (829-85-6)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at 25 - 67 ℃; for 16h;

DOI:10.1021/acs.organomet.0c00295

Reference yield: 55.0%

menthyl tosylate (2230-82-2) + Diphenylphosphine oxide (4559-70-0) → neomenthyldiphenylphosphine oxide (43077-30-1)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at 65 ℃; for 10h;

DOI:10.1246/bcsj.56.1871 DOI:10.1246/bcsj.56.219

Reference yield:

(1S,2R,4R)-2-bromo-1-isopropyl-4-methylcyclohexane + Diphenylphosphine oxide (4559-70-0) → neomenthyldiphenylphosphine oxide (43077-30-1) + (-)-menthyldiphenylphosphine oxide

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at 65 ℃; for 5.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1246/bcsj.56.219

upstream raw materials:

(1R,2S,5R)-menthyl chloride

Diphenylphosphine oxide

menthyl tosylate

triphenylphosphine