5-benzyl-3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one

Base Information

Chemical Name:5-benzyl-3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one
CAS No.:287401-33-6
Molecular Formula:C15H19NO2
Molecular Weight:245.31686
Hs Code.:
Mol file:287401-33-6.mol

Synonyms:2-Oxa-5-azaspiro[3.4]octan-1-one, 3,3-diMethyl-5-(phenylMethyl)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-benzyl-3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one

Chemical Property:

Vapor Pressure:2.93E-05mmHg at 25°C
Boiling Point:356.4°C at 760 mmHg
Flash Point:130.8°C
Density:1.16g/cm³

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-benzyl-3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one

There total 1 articles about 5-benzyl-3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 67-64-1
acetone

: phenyl (2S) 1-benzyl-2-pyrrolidine carboxylate

: 287401-33-6
5-benzyl-3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one

Guidance literature:: phenyl (2S) 1-benzyl-2-pyrrolidine carboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.583333h;

acetone; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Further stages.;
DOI:10.1021/ol0058792

Reference yield: 100.0%

: 287401-33-6
5-benzyl-3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one

: 287401-36-9
3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 0.5h; atmospheric pressure;
DOI:10.1021/ol0058792

Reference yield:

: 287401-33-6
5-benzyl-3,3-dimethyl-2-oxa-5-azaspiro[3.4]octan-1-one

: 287401-37-0
3,3,5-trimethyl-2-oxa-5-azaspiro[3.4]octan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / ethyl acetate / 0.5 h / atmospheric pressure

2: 93 percent / K₂CO₃ / dimethylformamide / 25 h / 30 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Methylation;
DOI:10.1021/ol0058792