2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin

Base Information

• Chemical Name: 2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin
• CAS No.: 52548-24-0
• Molecular Formula: C18H19ClN2S
• Molecular Weight: 330.87
• Mol file: 52548-24-0.mol

Synonyms:2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin;VUFB-12353

Chemical Property of 2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin

Chemical Property:

• PSA: 40.57000
• LogP: 4.26030

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin

There total 2 articles about 2-Chloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazine-1-carboxylic acid ethyl ester (52548-26-2) → 1-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazine (52548-24-0)

Guidance literature:

With potassium hydroxide; In water; ethylene glycol;

Reference yield:

→ 1-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazine (52548-24-0)

Guidance literature:

entspr. Thiepin II, alkal. Hydrolyse;

Reference yield:

1-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazine (52548-24-0) → [4-(2-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-yl]-[1-phenyl-meth-(E)-ylidene]-amine (86758-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / NaNO₂, aq. HCl / 1.) 75-80 deg C, 3 h, 2.) R_.T_., overnight.

2: 97 percent / LiAlH₄ / diethyl ether / 5 h / Ambient temperature

3: 84 percent / ethanol / 0.25 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sodium nitrite; In diethyl ether; ethanol;

DOI:10.1135/cccc19831173

upstream raw materials:

4-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazine-1-carboxylic acid ethyl ester

Downstream raw materials:

[4-(2-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-yl]-[1-phenyl-meth-(E)-ylidene]-amine

2-{[(E)-4-(2-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-ylimino]-methyl}-phenol

2-chloro-10-<4-(3,4-dimethoxybenzylideneamino)piperazino>-10,11-dihydrodibenzothiepin

2-chloro-10-<4-(3-ethoxy-4-hydroxybenzylideneamino)piperazino>-10,11-dihydrodibenzothiepin

Refernces

• 1、 -. "10,11-Dihydro-dibenzo(b,f)thiepin derivatives". . . Retrieved 2016/03/01.