3-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide

Base Information

Chemical Name:3-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide
CAS No.:208401-20-1
Molecular Formula:C₁₂H₉F₃N₂O₂
Molecular Weight:270.211
Hs Code.:
UNII:1L493ZB2GU
DSSTox Substance ID:DTXSID00174957
Wikidata:Q27252565
Mol file:208401-20-1.mol

Synonyms:208401-20-1;5-Desmethyl-3-methyl Leflunomide;3-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide;Leflunomide impurity E [EP];1L493ZB2GU;3-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide;UNII-1L493ZB2GU;4-Isoxazolecarboxamide, 3-methyl-N-(4-(trifluoromethyl)phenyl)-;3-Methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide;SCHEMBL3670697;DTXSID00174957;FT-0666146;LEFLUNOMIDE IMPURITY E [EP IMPURITY];Q27252565;3-methyl-4-[4- (trifluoromethyl)-phenylaminocarbonyl]isoxazole;3-methyl-4-[4-(trifluoromethyl)-phenylaminocarbonyl]isoxazole;3-methyl-4-[4-(trifluoromethyl)phenylaminocarbonyl]isoxazole;Leflunomide Imp. E (EP);Leflunomide Impurity E

Suppliers and Price of 3-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Desmethyl-3-methylLeflunomide
10mg
$ 185.00

Biosynth Carbosynth
5-Desmethyl-3-methyl leflunomide
25 mg
$ 496.00

Biosynth Carbosynth
5-Desmethyl-3-methyl leflunomide
10 mg
$ 272.60

Biosynth Carbosynth
5-Desmethyl-3-methyl leflunomide
5 mg
$ 150.00

Biosynth Carbosynth
5-Desmethyl-3-methyl leflunomide
100 mg
$ 1638.00

Biosynth Carbosynth
5-Desmethyl-3-methyl leflunomide
50 mg
$ 901.00

American Custom Chemicals Corporation
5-DESMETHYL-3-METHYL LEFLUNOMIDE 95.00%
5MG
$ 502.95

Total 11 raw suppliers

Chemical Property of 3-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide

Chemical Property:

Boiling Point:287.2±40.0 °C(Predicted)
PKA:11.45±0.70(Predicted)
PSA：55.13000
Density:1.392±0.06 g/cm3(Predicted)
LogP:3.32710
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:270.06161202
Heavy Atom Count:19
Complexity:327

Purity/Quality:

97% ^*data from raw suppliers

5-Desmethyl-3-methylLeflunomide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NOC=C1C(=O)NC2=CC=C(C=C2)C(F)(F)F
Uses The 3-methyl-isomer of Leflunomide (L322750), as a poisonous impurity. 5-Desmethyl-3-methyl Leflunomide (Leflunomide EP Impurity E) is the 3-methyl-isomer of Leflunomide (L322750), as a poisonous impurity.

Technology Process of 3-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide

There total 2 articles about 3-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: