4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Base Information

Chemical Name:4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
CAS No.:1500-90-9
Molecular Formula:C₇H₅N₅
Molecular Weight:159.15
Hs Code.:2933990090
DSSTox Substance ID:DTXSID60420548
Nikkaji Number:J80.210G
Wikidata:Q82231847
ChEMBL ID:CHEMBL168415
Mol file:1500-90-9.mol

Synonyms:4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile;1500-90-9;Toyocamycin Aglycone;CHEMBL168415;SCHEMBL7698538;DTXSID60420548;CS-0067317;4-amino-5-cyano-3h-pyrrolo[2,3-d]pyrimidine;D73402

Suppliers and Price of 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 95%+
1g
$ 1788.00

AccelPharmtech
4-amino-7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile 97.00%
25G
$ 6710.00

AccelPharmtech
4-amino-7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile 97.00%
5G
$ 3590.00

Total 6 raw suppliers

Chemical Property of 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Chemical Property:

PSA：91.38000
LogP:0.99298
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:159.05449518
Heavy Atom Count:12
Complexity:219

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C2=C(N=CN=C2N1)N)C#N

Technology Process of 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

There total 6 articles about 4-Amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 19393-83-0
4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine

: 1500-90-9
4-amino-5-cyanopyrrolo<2,3-d>pyrimidine

Guidance literature:: With ammonium hydroxide; 10% Pd/C; hydrogen; In ethanol; water; for 12h;
DOI:10.1002/adsc.201200109

Reference yield: 7.0%

: 118043-67-7
2-amino-5-cyano-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

: 118043-69-9
2-amino-5-cyano-7-<(1,3-dihydroxy-2-propoxy)methyl>pyrrolo<2,3-d>pyrimidine

: 118043-68-8
4-amino-5-cyano-7-<<1-(benzyloxy)-3-hydroxy-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

: 1500-90-9
4-amino-5-cyanopyrrolo<2,3-d>pyrimidine

Guidance literature:: With boron trichloride; In dichloromethane; a) - 78 deg C, 2 h, b) -60 deg C, 4 h;
DOI:10.1021/jm00122a019

Reference yield:

: 118043-66-6
4-amino-6-bromo-5-cyano-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>pyrrolo<2,3-d>pyrimidine

: 1500-90-9
4-amino-5-cyanopyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / hydrogen / 5percent Pd/C, MgO / ethyl acetate / 6 h / 2482.3 Torr

2: 10 percent / boron trichloride / CH₂Cl₂ / a) - 78 deg C, 2 h, b) -60 deg C, 4 h

With hydrogen; boron trichloride; palladium on activated charcoal; magnesium oxide; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00122a019