Benzenemethanamine, 2,4-difluoro-.alpha.-methyl-, hydrochloride (1:1), (.alpha.R)-

Base Information

• Chemical Name: Benzenemethanamine, 2,4-difluoro-.alpha.-methyl-, hydrochloride (1:1), (.alpha.R)-
• CAS No.: 791098-81-2
• Molecular Formula: C₈H₉F₂N*ClH
• Molecular Weight: 193.624
• Hs Code.: 2921490090
• Mol file: 791098-81-2.mol

Synonyms:Benzenemethanamine, 2,4-difluoro-.alpha.-methyl-, hydrochloride (1:1), (.alpha.R)-;(R)-1-(2,4-Difluorophenyl)ethylamine hydrochloride

Chemical Property of Benzenemethanamine, 2,4-difluoro-.alpha.-methyl-, hydrochloride (1:1), (.alpha.R)-

Chemical Property:

• PSA: 26.02000
• LogP: 3.48680
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-(2,4-Difluorophenyl)ethanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, 2,4-difluoro-.alpha.-methyl-, hydrochloride (1:1), (.alpha.R)-

There total 1 articles about Benzenemethanamine, 2,4-difluoro-.alpha.-methyl-, hydrochloride (1:1), (.alpha.R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (S)-1-(2,4-difluorophenyl)ethan-1-amine hydrochloride (844647-37-6,791098-81-2)

Guidance literature:

Reference yield:

(R)-1-(2,4-difluorophenyl)ethanamine hydrochloride (791098-81-2) + 1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid (1335210-23-5) → (R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate (1616340-73-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; for 1h;

Reference yield:

(R)-1-(2,4-difluorophenyl)ethanamine hydrochloride (791098-81-2) → (2S,5R,13aS)-N-((R)-1-(2,4-difluorophenyl)ethyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octaliydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide (1616339-78-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h

2.1: methanesulfonic acid; acetic acid / acetonitrile / 16 h / 75 °C

3.1: potassium carbonate / acetonitrile / 0.25 h / 90 °C / Sealed tube

3.2: 0.33 h / 50 °C

With methanesulfonic acid; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile;

Downstream raw materials:

(2S,5R,13aS)-N-((R)-1-(2,4-difluorophenyl)ethyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octaliydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dihydroxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 791098-81-2 Benzenemethanamine, 2,4-difluoro-.alpha.-methyl-, hydrochloride (1:1), (.alpha.R)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send