(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

Base Information

Chemical Name:(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate
CAS No.:1616340-73-8
Molecular Formula:C₂₁H₂₄F₂N₂O₇
Molecular Weight:454.428
Hs Code.:

Synonyms:(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

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Chemical Property of (R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

Chemical Property:

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Technology Process of (R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

There total 1 articles about (R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 791098-81-2
(R)-1-(2,4-difluorophenyl)ethanamine hydrochloride

: 1335210-23-5
1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

: 1616340-73-8
(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; for 1h;

Reference yield:

: 1616340-73-8
(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

: 1616340-74-9
(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dihydroxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

Guidance literature:: With methanesulfonic acid; acetic acid; In acetonitrile; at 75 ℃; for 16h;

Reference yield:

: 1616340-73-8
(R)-methyl 5-((1-(2,4-difluorophenyl)ethyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

: 1616339-78-6
(2S,5R,13aS)-N-((R)-1-(2,4-difluorophenyl)ethyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octaliydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonic acid; acetic acid / acetonitrile / 16 h / 75 °C

2.1: potassium carbonate / acetonitrile / 0.25 h / 90 °C / Sealed tube

2.2: 0.33 h / 50 °C

With methanesulfonic acid; potassium carbonate; acetic acid; In acetonitrile;