(R)-4-Bromo-2,3-dihydro-1H-inden-1-amine hydrochloride

Base Information

• Chemical Name: (R)-4-Bromo-2,3-dihydro-1H-inden-1-amine hydrochloride
• CAS No.: 1307231-02-2
• Molecular Formula: C9H11BrClN
• Molecular Weight: 248.54734
• Mol file: 1307231-02-2.mol

Synonyms:1H-Inden-1-amine, 4-bromo-2,3-dihydro-, hydrochloride (1:1), (1R)-

Chemical Property of (R)-4-Bromo-2,3-dihydro-1H-inden-1-amine hydrochloride

Chemical Property:

• PSA: 26.02000
• LogP: 3.89740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(1R)-4-Bromo-2,3-dihydro-1H-inden-1-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-Bromo-2,3-dihydro-1H-inden-1-amine hydrochloride

There total 3 articles about (R)-4-Bromo-2,3-dihydro-1H-inden-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-((R)-4-bromo-2,3-dihydro-1H-inden-1-yl)-2-methylpropane-2-sulfinamide (1307231-01-1) → (R)-4-bromo-2,3-dihydro-1H-inden-1-amine hydrochloride (1307231-02-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h; Reflux;

Reference yield:

4-bromo-2,3-dihydroinden-1-one (15115-60-3) → (R)-4-bromo-2,3-dihydro-1H-inden-1-amine hydrochloride (1307231-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium(IV) tetraethanolate / toluene / 18 h / 60 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C / Reflux

With hydrogenchloride; titanium(IV) tetraethanolate; In 1,4-dioxane; methanol; toluene;

Reference yield:

→ (R)-4-bromo-2,3-dihydro-1H-inden-1-amine hydrochloride (1307231-02-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.333333h;

upstream raw materials:

4-bromo-2,3-dihydroinden-1-one

(R)-N-((R)-4-bromo-2,3-dihydro-1H-inden-1-yl)-2-methylpropane-2-sulfinamide

Downstream raw materials:

tert-butyl (R)-(4-bromo-2,3-dihydro-1H-inden-1-yl)carbamate