15115-60-3

Basic information

• Product Name: 4-Bromo-1-indanone
• Synonyms: 4-bromo-2,3-dihydroinden-1-one;4-Bromo-1-indanone,97%;4-bromoindanone;4-BroMo-1-indanone, >95%;1H-Inden-1-one, 4-bromo-2,3-dihydro-;1-Indanone, 4-bromo-;4-Bromo-1-indanone≥ 98%(GC);4-bromo-1-indanon
• CAS NO: 15115-60-3
• Molecular Formula: C₉H₇BrO
• Molecular Weight: 211.06
• EINECS: 1533716-785-6
• Product Categories: Halides;API intermediates;Pharmaceutical intermediate;C9;Carbonyl Compounds;Ketones;Benzocycles
• Mol File: 15115-60-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 95-99 °C(lit.)
• Boiling Point: 125°C/1.5mmHg(lit.)
• Flash Point: 120.5 °C
• Appearance: Orange-brown/Crystalline Powder
• Density: 1.608 g/cm³
• Vapor Pressure: 0.000892mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Bromo-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1-indanone(15115-60-3)
• EPA Substance Registry System: 4-Bromo-1-indanone(15115-60-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-60-36
• WGK Germany: 2
• RTECS: NK7536100
• Hazardous Substances Data: 15115-60-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 15115-60-3 differently. You can refer to the following data:
1. 4-Bromo-1-indanone is used to prepare N'-indanyl-N-benzopyrazolyl ureas as TRPV1 antagonists for use as analgesics. It is also used to synthesize 1,4-dihydroindeno[1,2-c]pyrazoles as KDR kinase inhibitors.
2. 4-Bromo-1-indanone is used to prepare N''-indanyl-N-benzopyrazolyl ureas as TRPV1 antagonists for use as analgesics. It is also used to synthesize 1,4-dihydroindeno[1,2-c]pyrazoles as KDR kinase inhibitors.

Chemical Properties

Orange-brown crystalline powder

InChI:InChI=1/C9H7BrO/c10-8-3-1-2-7-6(8)4-5-9(7)11/h1-3H,4-5H2

Upstream product

• 83-33-0 inden-1-one 

Downstream Products

• 55934-10-6 methyl 1-oxo-2,3-dihydro-1H-indene-4-carboxylate 
• 1458652-60-2 methyl 2-((3S)-6-((1R)-4-(2,6-dimethyl-4-((tetrahydrofuran-3-yl)methoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate 
• 1307231-27-1 (R)-tert-butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)(4-(N-((4-phenyl-5-(trifluoromethyl)thiophene-2-carbonyl)oxy)carbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1307231-07-7 (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1306763-42-7 (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1306763-41-6 (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1307231-06-6 (R)-tert-butyl 4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylcarbamate 

Relevant articles and documents

Heteroatom bridged metallocene compounds for olefin polymerization

This invention relates to a transition metal compound represented by the formula: wherein M is a group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom; E is: 1) a substituted or unsubstituted indenyl ligand that is bonded to Y through the four, five, six or seven position of the indenyl ring, or 2) a substituted or unsubstituted heteroindenyl ligand that is bonded to Y through the four, five or six position of the heteroindenyl ring, provided that the bonding position is not the same as the position of the ring heteroatom, or 3) a substituted or unsubstituted fluorenyl ligand that is bonded to Y through the one, two, three, four, five, six, seven or eight position of the fluorenyl ring, or 4) a substituted or unsubstituted heterofluorenyl ligand that is bonded to Y through the one, two, three, four, five or six position of the heteroindenyl ring, provided that the bonding position is not the same as the position of the ring heteroatom; A is a substituted or unsubstituted cyclopentadienyl ligand, a substituted or unsubstituted heterocyclopentadienyl ligand, a substituted or unsubstituted indenyl ligand, a substituted or unsubstituted heteroindenyl ligand, a substituted or unsubstituted fluorenyl ligand, a substituted or unsubstituted heterofluorenyl ligand, or other mono-anionic ligand; Y is a Group 15 or 16 bridging heteroatom substituent that is bonded via the heteroatom to E and A; and X are, independently, univalent anionic ligands, or both X are joined and bound to the metal atom to form a metallocycle ring, or both X join to form a chelating ligand, a diene ligand, or an alkylidene ligand. This invention further relates to catalyst systems comprising the above transiotioon metal compounds, activators and optional supports and their use to polymerize or oligomerize olefins.

1-arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation

1-Arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and processes for making said derivatives are described. The novel derivatives are non-steroidal heterocyclic compounds which act as selective progestins and/or antiprogestins having a high in-vitro affinity for either the uterine, breast or bone progestin receptor. As such, the non-steroidal heterocyclic derivatives are useful in contraception, menopause, osteoporosis or endometriosis.