ledipasvir interMediate

Base Information

Chemical Name:ledipasvir interMediate
CAS No.:1256388-50-7
Molecular Formula:C29H29BrF2N4O3
Molecular Weight:599.475
Hs Code.:
Mol file:1256388-50-7.mol

Synonyms:Methyl (S)-1-((S)-6-(5-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-1H-iMidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-Methyl-1-oxobutan-2-ylcarbaMate;CarbaMic acid, N-[(1S)-1-[[(6S)-6-[5-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-1H-iMidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-Methylpropyl]-, Methyl ester;N-[(1S)-1-[[(6S)-6-[5-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

Suppliers and Price of ledipasvir interMediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
Methyl((S)-1-((S)-6-(5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate 95%+
100mg
$ 1800.00

Total 33 raw suppliers

Chemical Property of ledipasvir interMediate

Chemical Property:

Boiling Point:789.0±60.0 °C(Predicted)
PKA:11.13±0.10(Predicted)
PSA：87.32000
Density:1.53±0.1 g/cm3(Predicted)
LogP:6.72270

Purity/Quality:

98% ^*data from raw suppliers

Methyl((S)-1-((S)-6-(5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ledipasvir interMediate

There total 9 articles about ledipasvir interMediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₂₉H₂₉BrF₂N₂O₆

: 1256388-50-7
(1-{6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: With ammonium acetate; In 2-methoxy-ethanol; toluene; at 90 ℃; for 5h;

Reference yield:

: 1256388-49-4
6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1256388-50-7
(1-{6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: 6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester; With hydrogen bromide; acetic acid; In dichloromethane; at 20 ℃; for 3h;

N-methoxycarbonyl-L-valine; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.833333h;

Reference yield:

: (S)-6-(5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptane hydrochloride

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1256388-50-7
(1-{6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 12h;