2,7-dibromo-9,9-difluoro-9H-fluorene

Base Information

• Chemical Name: 2,7-dibromo-9,9-difluoro-9H-fluorene
• CAS No.: 1229603-71-7
• Molecular Formula: C₁₃H₆Br₂F₂
• Molecular Weight: 359.995
• Mol file: 1229603-71-7.mol

Synonyms:2,7-dibromo-9,9-difluoro-9H-fluorene

Chemical Property of 2,7-dibromo-9,9-difluoro-9H-fluorene

Chemical Property:

• Melting Point: 138.0 to 142.0 °C
• Boiling Point: 361.5±42.0 °C(Predicted)
• Density: 1.95±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2,7-Dibromo-9,9-difluorofluorene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,7-dibromo-9,9-difluoro-9H-fluorene

There total 4 articles about 2,7-dibromo-9,9-difluoro-9H-fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butyl-2,6-dimethylphenylsulfur trifluoride (947725-04-4) + 2,7-dibromofluorene-9-one (14348-75-5) → 4-tert-butyl-2,6-dimethylbenzenesulfinyl fluoride (1207990-88-2) + 2,7-dibromo-9,9-difluoro-9H-fluorene (1229603-71-7)

Guidance literature:

With pyridine; hydrogen fluoride; In toluene; at 77 ℃; for 24h;

Reference yield:

4-tert-butyl-2,6-dimethylphenylsulfur trifluoride (947725-04-4) + 2,7-dibromofluorene-9-one (14348-75-5) → 2,7-dibromo-9,9-difluoro-9H-fluorene (1229603-71-7) + potassium 4-tert-butyl-2,6-dimethylphenylsulfonate (1449225-56-2)

Guidance literature:

4-tert-butyl-2,6-dimethylphenylsulfur trifluoride; 2,7-dibromofluorene-9-one; With pyridine; hydrogen fluoride; In toluene; at 77 ℃; for 24h;

With ethanol; In toluene; at 0 ℃; for 0.5h; Further stages;

Reference yield:

4-tert-butyl-2,6-dimethylphenylsulfur trifluoride (947725-04-4) + ethanol (64-17-5) + 2,7-dibromofluorene-9-one (14348-75-5) → 2,7-dibromo-9,9-difluoro-9H-fluorene (1229603-71-7) + ethyl 4-tert-butyl-2,6-dimethylphenylsulfinate (1449225-57-3)

Guidance literature:

4-tert-butyl-2,6-dimethylphenylsulfur trifluoride; 2,7-dibromofluorene-9-one; With pyridine; hydrogen fluoride; In toluene; at 77 ℃; for 24h;

ethanol; In toluene; at 0 ℃; for 0.5h;

upstream raw materials:

4-tert-butyl-2,6-dimethylphenylsulfur trifluoride

ethanol

2,7-dibromofluorene-9-one

Downstream raw materials:

5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester

3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester

(1-{6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Refernces