3-Ethyl-1,5-dimethyl-3,7-diaza-bicyclo[3.3.1]-nonan-9-ol

Base Information

• Chemical Name: 3-Ethyl-1,5-dimethyl-3,7-diaza-bicyclo[3.3.1]-nonan-9-ol
• CAS No.: 104215-93-2
• Molecular Formula: C11H22N2O
• Molecular Weight: 198.30518
• Hs Code.: 2918990090
• Mol file: 104215-93-2.mol

Synonyms:3-Ethyl-1,5-dimethyl-3,7-diaza-bicyclo[3.3.1]-nonan-9-ol

Chemical Property of 3-Ethyl-1,5-dimethyl-3,7-diaza-bicyclo[3.3.1]-nonan-9-ol

Chemical Property:

• PSA: 35.50000
• LogP: 0.56530

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Methoxy-phenoxy)-butyric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethyl-1,5-dimethyl-3,7-diaza-bicyclo[3.3.1]-nonan-9-ol

There total 6 articles about 3-Ethyl-1,5-dimethyl-3,7-diaza-bicyclo[3.3.1]-nonan-9-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

ethyl 4-(2-methoxyphenoxy)butanoate (56359-21-8) → 4-(2-methoxyphenoxy)butanoic acid (104215-93-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.9b00462

Reference yield:

2-methoxy-phenol (90-05-1) → 4-(2-methoxyphenoxy)butanoic acid (104215-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: lithium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

With potassium carbonate; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.9b00462

Reference yield:

4-butanolide (96-48-0) + 2-methoxy-phenol (90-05-1) → 4-(2-methoxyphenoxy)butanoic acid (104215-93-2)

Guidance literature:

With sodium methylate; In methanol; Reflux;

DOI:10.1016/j.bmcl.2011.06.124

upstream raw materials:

4-(2-methoxy-phenoxy)-butyronitrile

1-(3-bromo-propoxy)-2-methoxy-benzene

4-butanolide

2-methoxy-phenol

Downstream raw materials:

3,4-dihydro-9-methoxy-1-benzoxepin-5(2H)-one

4-(2-Methoxy-phenoxy)-butyric acid 2-methoxy-phenyl ester

C₁₇H₁₉NO₅