5-Bromo-N,4-dimethyl-2-pyridinamine

Base Information

• Chemical Name: 5-Bromo-N,4-dimethyl-2-pyridinamine
• CAS No.: 155789-99-4
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.066
• Hs Code.: 2933399090
• Mol file: 155789-99-4.mol

Synonyms:5-Bromo-N,4-dimethyl-2-pyridinamine;5-Bromo-2-methylamino-4-picoline;5-Bromo-N,4-dimethylpyridin-2-amine

Chemical Property of 5-Bromo-N,4-dimethyl-2-pyridinamine

Chemical Property:

• Boiling Point: 267.1±40.0 °C(Predicted)
• PKA: 5.59±0.10(Predicted)
• PSA: 24.92000
• Density: 1.494±0.06 g/cm3(Predicted)
• LogP: 2.26720
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-methylamino-4-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-N,4-dimethyl-2-pyridinamine

There total 4 articles about 5-Bromo-N,4-dimethyl-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

2-(methylamino)-4-methylpyridine (45699-12-5) → 5-bromo-4-methyl-2-methylaminopyridine (155789-99-4) + 3,5-dibromo-4-methyl-2-methylaminopyridine

Guidance literature:

With bromine; In acetic acid; at 20 ℃; for 1h;

Reference yield:

Benzotriazol-1-ylmethyl-(4-bromo-6-methyl-pyridin-2-yl)-amine → 5-bromo-4-methyl-2-methylaminopyridine (155789-99-4)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 8h; Yield given; Heating;

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → 5-bromo-4-methyl-2-methylaminopyridine (155789-99-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 5 h / 20 °C

2: NaBH₄ / tetrahydrofuran / 8 h / Heating

3: 48 percent / Br₂ / acetic acid / 1 h / 20 °C

With sodium tetrahydroborate; bromine; In tetrahydrofuran; ethanol; acetic acid;

upstream raw materials:

2-(methylamino)-4-methylpyridine

2-Amino-4-methylpyridine

Benzotriazol-1-ylmethyl-(4-methyl-pyridin-2-yl)-amine

Downstream raw materials:

5-bromo-4-methyl-2-methylamino-3-nitropyridine

2-methylamino-3-amino-4-methylpyridine

2-N-methylamino-3-nitro-4-methylpyridine

Refernces