2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide

Base Information

Chemical Name:2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide
CAS No.:503155-67-7
Molecular Formula:C46H45N7O2
Molecular Weight:727.909
Hs Code.:
Mol file:503155-67-7.mol

Synonyms:2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide;2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-phenyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylacetaMide coMpound with 1,1'-biphenyl (1:1);2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylacetaMide

Suppliers and Price of 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 36 raw suppliers

Chemical Property of 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide

Chemical Property:

Boiling Point:882.1±75.0 °C(Predicted)
PKA:1.36±0.70(Predicted)
PSA：98.80000
Density:1.17
LogP:7.73400

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide

There total 7 articles about 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2-(2-n-butyl-4-hydroxy-6-methylpyrimidin-5-yl) -N,N-dimethylacetamide

: 124750-51-2
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

: 503155-67-7
2-n-butyl-5-dimethylaminocarbonylmethyl-6-methyl-3-[[2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one

Guidance literature:: With lithium hydroxide; In N,N-dimethyl-formamide; toluene; at 60 - 65 ℃; for 24h;

Reference yield:

: 503155-65-5
C₁₃H₂₀N₂O₃

: 503155-67-7
2-n-butyl-5-dimethylaminocarbonylmethyl-6-methyl-3-[[2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydride / ethyl acetate; N,N-dimethyl-formamide

2: water; sodium hydroxide / methanol / 20 °C

3: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / chloroform

With 4-methyl-morpholine; water; lithium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.116

Reference yield:

: 503155-66-6
C₄₆H₄₄N₆O₃

: 503155-67-7
2-n-butyl-5-dimethylaminocarbonylmethyl-6-methyl-3-[[2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / chloroform

With 4-methyl-morpholine; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; chloroform;
DOI:10.1016/j.bmcl.2011.12.116