Technology Process of 2-(4-bromophenoxy)-5-methoxynicotinic acid
There total 4 articles about 2-(4-bromophenoxy)-5-methoxynicotinic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromo-phenol;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 23 ℃;
for 0.116667h;
Inert atmosphere;
2-fluoro-5-methoxynicotinic acid;
In
N,N-dimethyl-formamide;
at 130 - 140 ℃;
for 23h;
Inert atmosphere;
DOI:10.1021/jm5012676
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 12.5 h / -70 °C
2.2: -70 - 0 °C
2.3: 0 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C
3.2: 140 °C
3.3: 20 °C / Cooling with ice
With
n-butyllithium; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran / 3 h / 0 - 20 °C
1.2: 20 °C / pH 7
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 12.5 h / -70 °C
3.2: -70 - 0 °C
3.3: 0 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C
4.2: 140 °C
4.3: 20 °C / Cooling with ice
With
n-butyllithium; dihydrogen peroxide; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide;
